Increased prevalence of irritable bowel syndrome in migraine patients: A systematic review and meta-analysis
Issued Date
2022-01-01
Resource Type
ISSN
0954691X
eISSN
14735687
Scopus ID
2-s2.0-85122487800
Pubmed ID
33470704
Journal Title
European Journal of Gastroenterology and Hepatology
Volume
34
Issue
1
Start Page
56
End Page
63
Rights Holder(s)
SCOPUS
Bibliographic Citation
European Journal of Gastroenterology and Hepatology Vol.34 No.1 (2022) , 56-63
Suggested Citation
Wongtrakul W. Increased prevalence of irritable bowel syndrome in migraine patients: A systematic review and meta-analysis. European Journal of Gastroenterology and Hepatology Vol.34 No.1 (2022) , 56-63. 63. doi:10.1097/MEG.0000000000002065 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86707
Title
Increased prevalence of irritable bowel syndrome in migraine patients: A systematic review and meta-analysis
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Objective Even though evidence showing increased prevalence of irritable bowel syndrome (IBS) among migraine patients exists, it has not been well-established and the magnitude of association varies substantially across the studies. This study aimed to comprehensively compare the prevalence of IBS among migraineurs versus nonmigraineurs using the systematic review and the meta-analysis technique. Methods Two authors independently conducted a literature search in MEDLINE, EMBASE and Google Scholar database up to April 2020. The eligible study must consist of two groups of participants, migraineurs and nonmigraineurs, and report the prevalence of IBS in both groups. Alternatively, an eligible study may report the odds ratio (OR) with a 95% confidence interval (CI) of the association between migraine and IBS. Point estimates and standard errors from each eligible study were combined together using the generic inverse variance method of DerSimonian and Laird. Results Of the 2531 articles identified from the three databases, 11 studies with a total of 28 336 migraineurs and 1 535 758 nonmigraineurs met the selection criteria and were included into the meta-analysis. The pooled analysis found that migraineurs had a significantly higher prevalence of IBS than nonmigraineurs with the pooled OR of 2.49 (95% CI, 2.22-2.78; I2, 42%). The funnel plot was asymmetric and suggested the presence of publication bias. Conclusion A significantly increased prevalence of IBS among patients with migraine was demonstrated in this study.
