The role of ncRNA regulatory mechanisms in diseases—case on gestational diabetes
Issued Date
2024-01-01
Resource Type
ISSN
14675463
eISSN
14774054
Scopus ID
2-s2.0-85182017449
Pubmed ID
38189542
Journal Title
Briefings in Bioinformatics
Volume
25
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Briefings in Bioinformatics Vol.25 No.1 (2024)
Suggested Citation
Gao D., Ren L., Hao Y.D., Schaduangrat N., Liu X.W., Yuan S.S., Yang Y.H., Wang Y., Shoombuatong W., Ding H. The role of ncRNA regulatory mechanisms in diseases—case on gestational diabetes. Briefings in Bioinformatics Vol.25 No.1 (2024). doi:10.1093/bib/bbad489 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/95682
Title
The role of ncRNA regulatory mechanisms in diseases—case on gestational diabetes
Corresponding Author(s)
Other Contributor(s)
Abstract
Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not have the potential to encode proteins. Meanwhile, they can occupy a significant portion of the human genome and participate in gene expression regulation through various mechanisms. Gestational diabetes mellitus (GDM) is a pathologic condition of carbohydrate intolerance that begins or is first detected during pregnancy, making it one of the most common pregnancy complications. Although the exact pathogenesis of GDM remains unclear, several recent studies have shown that ncRNAs play a crucial regulatory role in GDM. Herein, we present a comprehensive review on the multiple mechanisms of ncRNAs in GDM along with their potential role as biomarkers. In addition, we investigate the contribution of deep learning-based models in discovering disease-specific ncRNA biomarkers and elucidate the underlying mechanisms of ncRNA. This might assist community-wide efforts to obtain insights into the regulatory mechanisms of ncRNAs in disease and guide a novel approach for early diagnosis and treatment of disease.