Imaging Method by Matrix-Assisted Laser Desorption/ Ionization Mass Spectrometry (MALDI-MS) for Tissue or Tumor: A Mini Review
Issued Date
2022-02-01
Resource Type
eISSN
22279717
Scopus ID
2-s2.0-85125105760
Journal Title
Processes
Volume
10
Issue
2
Rights Holder(s)
SCOPUS
Bibliographic Citation
Processes Vol.10 No.2 (2022)
Suggested Citation
Wu J., Rong Z., Xiao P., Li Y. Imaging Method by Matrix-Assisted Laser Desorption/ Ionization Mass Spectrometry (MALDI-MS) for Tissue or Tumor: A Mini Review. Processes Vol.10 No.2 (2022). doi:10.3390/pr10020388 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/84107
Title
Imaging Method by Matrix-Assisted Laser Desorption/ Ionization Mass Spectrometry (MALDI-MS) for Tissue or Tumor: A Mini Review
Other Contributor(s)
Abstract
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is an ad-vanced technique that uses minimum fragmented ions from complex molecules for mass spectrome-try (MS) analysis (tissue profiling by mass spectrometry). It is able to analyze spatially resolved tissue or tumor sections at the molecular level. It has become a valuable tool for tumor and tissue imaging, due to its ease of operation and high mass resolution, but it still has vast room for development in the instrumentation of larger proteins in some tissues. In this review, we focus on the main components of MALDI-MS instrumentation, sample handling and processing, the working principle of MALDI-MS, and its applications in diagnostic and prognostic assessments, tumor removal and drug development. Although it is less effective at detecting larger proteins in some tissues, it still shows huge potential because of its advancements in instrumentation and processing protocols. This article may benefit those who have interests in MALDI-MS for tissue or tumor imaging.