Comparison of the Cerumenolytic Activities of New and Currently Used Agents
1
Issued Date
2022-02-01
Resource Type
ISSN
01455613
eISSN
19427522
Scopus ID
2-s2.0-85100565986
Pubmed ID
33512244
Journal Title
Ear, Nose and Throat Journal
Volume
101
Issue
2
Start Page
31S
End Page
36S
Rights Holder(s)
SCOPUS
Bibliographic Citation
Ear, Nose and Throat Journal Vol.101 No.2 (2022) , 31S-36S
Suggested Citation
Anh N.Q. Comparison of the Cerumenolytic Activities of New and Currently Used Agents. Ear, Nose and Throat Journal Vol.101 No.2 (2022) , 31S-36S. 36S. doi:10.1177/0145561320986060 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/86195
Title
Comparison of the Cerumenolytic Activities of New and Currently Used Agents
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Objectives: This study compared the cerumen dissolution activities of 7.5% sodium bicarbonate, 5% potassium hydroxide, 10% lactic acid, 3% salicylic acid, 10% glycolic acid, and distilled water. Methods: An in vitro study was conducted with 36 cerumen samples. The cerumenolytic activities of the 6 agents were assessed by recording the degree of cerumen disintegration using digital photography at 15 minutes, 30 minutes, 1 hour, 2 hours, and 12 hours. The undissolved cerumen that remained after 12 hours was removed from the solutions and weighed after drying. Results: Potassium hydroxide showed the fastest cerumenolytic activity, dissolving a moderate amount of cerumen at 30 minutes, while glycolic acid and salicylic acid caused no visible changes in the cerumen samples. Samples treated with potassium hydroxide and sodium bicarbonate exhibited higher degrees of disintegration compared to samples treated with distilled water (odds ratio and 95% CI: 273.237 [0.203-367 470.4] and 1.129 [0.002-850.341], respectively). The greatest reduction in cerumen weight was associated with the use of sodium bicarbonate; however, this result did not reach statistical significance. Conclusions: Among the solutions tested, 5% potassium hydroxide showed the fastest dissolution activity, yielding moderate disintegration within only 30 minutes. In terms of residual cerumen weight within 12 hours, all solutions exhibited equivalent effectiveness in the disintegration of cerumen.