Interleukin-5 levels in relation to malaria severity: a systematic review
Issued Date
2023-08-03
Resource Type
eISSN
14752875
Scopus ID
2-s2.0-85166559039
Pubmed ID
37537570
Journal Title
Malaria journal
Volume
22
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Malaria journal Vol.22 No.1 (2023) , 226
Suggested Citation
Kotepui M., Duangchan T., Mahittikorn A., Mekhora C., Anabire N.G., Kotepui K.U. Interleukin-5 levels in relation to malaria severity: a systematic review. Malaria journal Vol.22 No.1 (2023) , 226. doi:10.1186/s12936-023-04659-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/88312
Title
Interleukin-5 levels in relation to malaria severity: a systematic review
Other Contributor(s)
Abstract
BACKGROUND: The role of cytokines such as interleukin-5 (IL-5) in the pathogenesis of malaria remains unclear. This systematic review sought to synthesize variations in IL-5 levels between severe and uncomplicated malaria, as well as between malaria and controls not afflicted with the disease. METHODS: This systematic review was registered at the International Prospective Register of Systematic Reviews (PROSPERO; CRD42022368773). Searches for studies that reported IL-5 levels in patients with malaria (any severity) and/or uninfected individuals were performed in Web of Science, PubMed, EMBASE, Scopus, CENTRAL, and MEDLINE, between 1st and 10th October, 2022. The risk of bias among all included studies was minimized using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines for reporting observational studies. The differences in IL-5 levels between malaria and uninfected controls, and between severe and uncomplicated malaria were synthesized by narrative synthesis. RESULTS: Among 1177 articles identified in the databases, 23 matched the eligibility criteria and were included in this systematic review. Qualitative syntheses showed the heterogeneity of IL-5 levels between different severities of clinical malaria and uninfected controls. The majority of the included studies (12/15 studies, 80%) found no change in IL-5 levels between malaria cases and uninfected controls. Similarly, most studies found no difference in IL-5 levels between severe (regardless of complications) and uncomplicated malaria (4/8 studies, 50%). The qualitative syntheses revealed that most studies found no difference in IL-5 levels between severe and non-severe malaria. CONCLUSIONS: The comprehensive review suggests that IL-5 levels are unchanged in patients with different levels of clinical severity of malaria and uninfected controls. Given the limited number of published studies on IL-5 levels in malaria, there is a need for additional research to determine the function of this cytokine in the pathogenesis of malaria.