Updating on Roles of HIV Intrinsic Factors: A Review of Their Antiviral Mechanisms and Emerging Functions
Issued Date
2022-01-01
Resource Type
ISSN
03005526
eISSN
14230100
Scopus ID
2-s2.0-85128161447
Pubmed ID
34464956
Journal Title
Intervirology
Volume
65
Issue
2
Start Page
67
End Page
79
Rights Holder(s)
SCOPUS
Bibliographic Citation
Intervirology Vol.65 No.2 (2022) , 67-79
Suggested Citation
Hadpech S., Moonmuang S., Chupradit K., Yasamut U., Tayapiwatana C. Updating on Roles of HIV Intrinsic Factors: A Review of Their Antiviral Mechanisms and Emerging Functions. Intervirology Vol.65 No.2 (2022) , 67-79. 79. doi:10.1159/000519241 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85055
Title
Updating on Roles of HIV Intrinsic Factors: A Review of Their Antiviral Mechanisms and Emerging Functions
Author's Affiliation
Other Contributor(s)
Abstract
Background: Host restriction factors are cellular proteins that inhibit specific steps of the viral life cycle. Since the 1970s, several new factors have been identified, including human immunodeficiency virus-1 (HIV-1) replication restriction. Evidence accumulated in the last decade has substantially broadened our understanding of the molecular mechanisms utilized to abrogate the HIV-1 life cycle. Summary: In this review, we focus on the interaction between host restriction factors participating in the early phase of HIV-1 infection, particularly CA-targeting proteins. Host factors involved in the late phase of the replication cycle, such as viral assembly and egress factors, are also described. Additionally, current reports on well-known antiviral intrinsic factors, as well as other viral restriction factors with their emerging roles, are included. Conclusion: A comprehensive understanding of the interactions between viruses and hosts is expected to provide insight into the design of novel HIV-1 therapeutic interventions.