Establishment of the integration-free Class I and Class II 11 loci homozygous HLA iPSC line (MUSIi023-A) from peripheral blood mononuclear cells of a Thai donor

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dc.contributor.authorJiamvoraphong N.
dc.contributor.authorNimsamer P.
dc.contributor.authorWongsurawat T.
dc.contributor.authorLorthongpanich C.
dc.contributor.authorLaowtammathron C.
dc.contributor.authorIssaragrisil S.
dc.contributor.correspondenceJiamvoraphong N.
dc.contributor.otherMahidol University
dc.date.accessioned2025-10-13T18:11:22Z
dc.date.available2025-10-13T18:11:22Z
dc.date.issued2025-10-01
dc.description.abstractPluripotent stem cell (PSC)-based technologies offer a promising new approach to generating functional cells or grafts for transplantation. To minimize the risk of immune rejection, induced pluripotent stem cells (iPSCs) that are homozygous for HLA Class I and Class II genes are a potential solution to reduce the risk of immune rejection in regenerative medicine applications. In this study, MUSIi023-A iPSC line was generated from peripheral blood mononuclear cells of a Thai donor with 11 loci homozygous HLA. This cell line is free of viral integration, exhibited pluripotent stem cell characteristics and able to differentiate to all embryonic lineages.
dc.identifier.citationStem Cell Research Vol.88 (2025)
dc.identifier.doi10.1016/j.scr.2025.103840
dc.identifier.eissn18767753
dc.identifier.issn18735061
dc.identifier.pmid41033103
dc.identifier.scopus2-s2.0-105017966998
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/112555
dc.rights.holderSCOPUS
dc.subjectBiochemistry, Genetics and Molecular Biology
dc.subjectMedicine
dc.titleEstablishment of the integration-free Class I and Class II 11 loci homozygous HLA iPSC line (MUSIi023-A) from peripheral blood mononuclear cells of a Thai donor
dc.typeArticle
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105017966998&origin=inward
oaire.citation.titleStem Cell Research
oaire.citation.volume88
oairecerif.author.affiliationSiriraj Hospital

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