The synthesis of Tween80/calcium phosphate nanocomposite bioactive gelatine-based gels as a proof of concept for tooth sensitivity home-treatment
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2023-08-02
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item.page.dc.identifier.eissn
18811361
item.page.dc.identifier.doi
item.page.dc.identifier.scopus
2-s2.0-85166442012
item.page.dc.identifier.pmid
37302823
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Dental materials journal
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42
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4
item.page.oaire.citation.startPage
568
item.page.oaire.citation.endPage
574
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SCOPUS
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Dental materials journal Vol.42 No.4 (2023) , 568-574
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Maimansomsuk S., Thongnasan N., Harnkla P., Teanchai C., Sinthuvanich C., Akkarachaneeyakorn K. The synthesis of Tween80/calcium phosphate nanocomposite bioactive gelatine-based gels as a proof of concept for tooth sensitivity home-treatment. Dental materials journal Vol.42 No.4 (2023) , 568-574. 574. doi:10.4012/dmj.2022-277 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/88278
item.page.dc.title
The synthesis of Tween80/calcium phosphate nanocomposite bioactive gelatine-based gels as a proof of concept for tooth sensitivity home-treatment
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item.page.dc.description.abstract
Dentine hypersensitivity interferes with the lifestyle owing to pain arising from exposed dentine surfaces in response to stimuli. One common way to treat this problem is to occlude the exposed tubules. In this work, we have proposed a home-based treatment gel for tooth sensitivity. The gel was prepared using the emulsion method and contained Tween80/calcium phosphate nanocomposite that could occlude the tubules after 10 h of application. In preparation, Tween80 was used as a surfactant, and oleic acid was used as an oil phase to form a water-in-oil nanoreactor for calcium phosphate synthesis. Finally, different concentrations of gelatine were used to transform the emulsion into a stable gel. The nanoparticles had a uniform spherical shape and a diameter of approximately 300 nm. The nanocomposite gel containing the lowest amount of gelatine (Gel-T80-5%GE) exhibited the best liquid-like property and the highest occlusion rate of 95%.