Trends in hepatitis C virus coinfection and its cascade of care among adults living with HIV in Asia between 2010 and 2020
Issued Date
2023-01-01
Resource Type
eISSN
19326203
Scopus ID
2-s2.0-85163580154
Pubmed ID
37379314
Journal Title
PloS one
Volume
18
Issue
6
Rights Holder(s)
SCOPUS
Bibliographic Citation
PloS one Vol.18 No.6 (2023) , e0287909
Suggested Citation
Ross J., Rupasinghe D., Avihingsanon A., Lee M.P., Pujari S., Sharp G., Kumarasamy N., Khusuwan S., Khol V., Somia I.K.A., Pham T.N., Kiertiburanakul S., Choi J.Y., Do C.D., Sohn A.H., Jiamsakul A. Trends in hepatitis C virus coinfection and its cascade of care among adults living with HIV in Asia between 2010 and 2020. PloS one Vol.18 No.6 (2023) , e0287909. doi:10.1371/journal.pone.0287909 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87977
Title
Trends in hepatitis C virus coinfection and its cascade of care among adults living with HIV in Asia between 2010 and 2020
Author's Affiliation
Ramathibodi Hospital
The Voluntary Health Services, Chennai
Bach Mai Hospital
Universitas Udayana
The Kirby Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Yonsei University College of Medicine
Queen Elizabeth Hospital Hong Kong
Faculty of Medicine, Chulalongkorn University
National Hospital for Tropical Diseases
Foundation for AIDS Research
Institute of Infectious Diseases
Chiangrai Prachanukroh Hospital
National Center for HIV/AIDS
The Voluntary Health Services, Chennai
Bach Mai Hospital
Universitas Udayana
The Kirby Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Yonsei University College of Medicine
Queen Elizabeth Hospital Hong Kong
Faculty of Medicine, Chulalongkorn University
National Hospital for Tropical Diseases
Foundation for AIDS Research
Institute of Infectious Diseases
Chiangrai Prachanukroh Hospital
National Center for HIV/AIDS
Other Contributor(s)
Abstract
BACKGROUND: Chronic hepatitis C virus (HCV) infection contributes to substantial morbidity and mortality among adults living with HIV. Cascades of HCV care support monitoring of program performance, but data from Asia are limited. We assessed regional HCV coinfection and cascade outcomes among adults living with HIV in care from 2010-2020. METHODS: Patients ≥18 years old with confirmed HIV infection on antiretroviral therapy (ART) at 11 clinical sites in Cambodia, China, India, Indonesia, South Korea, Thailand and Vietnam were included. HCV- and HIV-related treatment and laboratory data were collected from those with a positive HCV antibody (anti-HCV) test after January 2010. An HCV cascade was evaluated, including proportions positive for anti-HCV, tested for HCV RNA or HCV core antigen (HCVcAg), initiated on HCV treatment, and achieved sustained virologic response (SVR). Factors associated with screening uptake, treatment initiation, and treatment response were analyzed using Fine and Gray's competing risk regression model. RESULTS: Of 24,421 patients, 9169 (38%) had an anti-HCV test, and 971 (11%) had a positive result. The proportion with positive anti-HCV was 12.1% in 2010-2014, 3.9% in 2015-2017, and 3.8% in 2018-2020. From 2010 to 2014, 34% with positive anti-HCV had subsequent HCV RNA or HCVcAg testing, 66% initiated HCV treatment, and 83% achieved SVR. From 2015 to 2017, 69% with positive anti-HCV had subsequent HCV RNA or HCVcAg testing, 59% initiated HCV treatment, and 88% achieved SVR. From 2018 to 2020, 80% had subsequent HCV RNA or HCVcAg testing, 61% initiated HCV treatment, and 96% achieved SVR. Having chronic HCV in later calendar years and in high-income countries were associated with increased screening, treatment initiation or achieving SVR. Older age, injecting drug use HIV exposure, lower CD4 and higher HIV RNA were associated with reduced HCV screening or treatment initiation. CONCLUSIONS: Our analysis identified persistent gaps in the HCV cascade of care, highlighting the need for focused efforts to strengthen chronic HCV screening, treatment initiation, and monitoring among adult PLHIV in the Asia region.