Outcomes of micropulse transscleral cyclophotocoagulation using different sweep velocity in the treatment of refractory glaucoma
Issued Date
2025-12-01
Resource Type
eISSN
20452322
Scopus ID
2-s2.0-105026213868
Pubmed ID
41462358
Journal Title
Scientific Reports
Volume
15
Issue
1
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SCOPUS
Bibliographic Citation
Scientific Reports Vol.15 No.1 (2025)
Suggested Citation
Jiravarnsirikul A., Jiamjira-Anon N., Ruangvaravate N., Sakiyalak D., Kitnarong N., Phongsuphan T., Sermsripong W., Petchyim S. Outcomes of micropulse transscleral cyclophotocoagulation using different sweep velocity in the treatment of refractory glaucoma. Scientific Reports Vol.15 No.1 (2025). doi:10.1038/s41598-025-28423-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/113966
Title
Outcomes of micropulse transscleral cyclophotocoagulation using different sweep velocity in the treatment of refractory glaucoma
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Abstract
This study compared the efficacy and safety of micropulse transscleral cyclophotocoagulation (MP-TSCPC) using different sweep velocities in refractory glaucoma. Twenty-eight eyes of 28 patients were treated with a slow-sweep protocol (20 s × 4 sweeps per hemisphere, fluence = 104.8 J/cm<sup>2</sup>), and 29 eyes of 26 patients were treated with a regular-sweep protocol (10 s × 8 sweeps per hemisphere, fluence = 52.4 J/cm<sup>2</sup>). Patients were evaluated at 1, 3, and 6 months to assess intraocular pressure (IOP), best-corrected visual acuity (BCVA), number of medications, and complications. The regular-sweep group achieved significantly greater mean IOP reduction at 1 month (–12.1 vs. − 4.8 mmHg, P < 0.001) and 3 months (–10.5 vs. − 3.6 mmHg, P = 0.003). At 6 months, no significant change in BCVA from baseline was observed in either group (all P > 0.05), while both protocols significantly reduced topical IOP-lowering medication use (all P < 0.05). Complication rates did not differ significantly between groups (P = 0.738). Multivariable analysis identified higher baseline IOP (P = 0.005) and the regular-sweep protocol (P < 0.001) as predictors of greater IOP reduction. In refractory glaucoma, both regular- and slow-sweep velocity protocols of MP-TSCPC demonstrated effectiveness with a similar safety profile in IOP reduction after a short follow-up period.