Non-ionic surfactant-assisted controlled release of oxyresveratrol on dendritic fibrous silica for topical applications
Issued Date
2023-09-15
Resource Type
ISSN
00219797
eISSN
10957103
Scopus ID
2-s2.0-85159445057
Journal Title
Journal of Colloid and Interface Science
Volume
646
Start Page
342
End Page
353
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Colloid and Interface Science Vol.646 (2023) , 342-353
Suggested Citation
Kerdmuanglek F., Chomtong T., Boonsith S., Chutimasakul T., Iemsam-arng J., Thepwatee S. Non-ionic surfactant-assisted controlled release of oxyresveratrol on dendritic fibrous silica for topical applications. Journal of Colloid and Interface Science Vol.646 (2023) , 342-353. 353. doi:10.1016/j.jcis.2023.05.050 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82851
Title
Non-ionic surfactant-assisted controlled release of oxyresveratrol on dendritic fibrous silica for topical applications
Other Contributor(s)
Abstract
We present a simple and eco-friendly method for controlled drug release using a surfactant-assisted method. Oxyresveratrol (ORES) was co-loaded with a non-ionic surfactant onto KCC-1, a dendritic fibrous silica, using an ethanol evaporation technique. The carriers were characterized using FE-SEM, TEM, XRD, N2 adsorption–desorption, FTIR, and Raman spectroscopy, and the loading and encapsulation efficiencies were assessed using TGA and DSC techniques. Contact angle and zeta potential were used to determine the surfactant arrangement and the particle charges. To investigate the effects of different surfactants (Tween 20, Tween 40, Tween 80, Tween 85, and Span 80) on ORES release, we conducted experiments under different pH and temperature conditions. Results showed that the types of surfactants, drug loading content, pH, and temperature significantly affected the drug release profile. The percentage of drug loading efficiency of the carriers was in the range of 80 %–100 %, and the release of ORES was in the order of M/KCC-1 > M/K/S80 > M/K/T40 > M/K/T20 > MK/T80 > M/K/T85 at 24 h. Furthermore, the carriers provided excellent protection for ORES against UVA and maintained its antioxidant activity. KCC-1 and Span 80 enhanced the cytotoxicity to HaCaT cells, while Tween 80 suppressed the cytotoxicity.