Revisiting luteolin: An updated review on its anticancer potential
Issued Date
2024-03-15
Resource Type
ISSN
24058440
Scopus ID
2-s2.0-85186491201
Journal Title
Heliyon
Volume
10
Issue
5
Rights Holder(s)
SCOPUS
Bibliographic Citation
Heliyon Vol.10 No.5 (2024)
Suggested Citation
Rauf A., Wilairatana P., Joshi P.B., Ahmad Z., Olatunde A., Hafeez N., Hemeg H.A., Mubarak M.S. Revisiting luteolin: An updated review on its anticancer potential. Heliyon Vol.10 No.5 (2024). doi:10.1016/j.heliyon.2024.e26701 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97539
Title
Revisiting luteolin: An updated review on its anticancer potential
Corresponding Author(s)
Other Contributor(s)
Abstract
Numerous natural products found in our diet, such as polyphenols and flavonoids, can prevent the progression of cancer. Luteolin, a natural flavone, present in significant amounts in various fruits and vegetables plays a key role as a chemopreventive agent in treating various types of cancer. By inducing apoptosis, initiating cell cycle arrest, and decreasing angiogenesis, metastasis, and cell proliferation, luteolin is used to treat cancer. Its anticancer properties are attributed to its capability to engage with multiple molecular targeted sites and modify various signaling pathways in tumor cells. Luteolin has been shown to slow the spread of cancer in breast, colorectal, lung, prostate, liver, skin, pancreatic, oral, and gastric cancer models. It exhibits antioxidant properties and can be given to patients receiving Doxorubicin (DOX) chemotherapy to prevent the development of unexpected adverse reactions in the lungs and hematopoietic system subjected to DOX. Furthermore, it could be an excellent candidate for synergistic studies to overcome drug resistance in cancer cells. Accordingly, this review covers the recent literature related to the use of luteolin against different types of cancer, along with the mechanisms of action. In addition, the review highlights luteolin as a complementary medicine for preventing and treating cancer.