Potentially modifiable ventilation factors associated with outcome in neurocritical care vs. non-neurocritical care patients: Rational and protocol for a patient-level analysis of PRoVENT, PRoVENT-iMiC and ENIO (PRIME)
Issued Date
2025-01-01
Resource Type
ISSN
00349356
Scopus ID
2-s2.0-85216277843
Journal Title
Revista Espanola de Anestesiologia y Reanimacion
Rights Holder(s)
SCOPUS
Bibliographic Citation
Revista Espanola de Anestesiologia y Reanimacion (2025)
Suggested Citation
Serafini S.C., Cinotti R., Asehnoune K., Battaglini D., Robba C., Neto A.S., Pisani L., Mazzinari G., Tschernko E.M., Schultz M.J. Potentially modifiable ventilation factors associated with outcome in neurocritical care vs. non-neurocritical care patients: Rational and protocol for a patient-level analysis of PRoVENT, PRoVENT-iMiC and ENIO (PRIME). Revista Espanola de Anestesiologia y Reanimacion (2025). doi:10.1016/j.redar.2024.501690 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/104178
Title
Potentially modifiable ventilation factors associated with outcome in neurocritical care vs. non-neurocritical care patients: Rational and protocol for a patient-level analysis of PRoVENT, PRoVENT-iMiC and ENIO (PRIME)
Author's Affiliation
Mahidol Oxford Tropical Medicine Research Unit
Melbourne Medical School
IRCCS San Martino Polyclinic Hospital
Instituto de Investigación Sanitaria La Fe
Hospital Universitari i Politècnic La Fe
CHU de Nantes
University of Melbourne
Università degli Studi di Genova
Monash University
Hospital Israelita Albert Einstein
Medizinische Universität Wien
Nuffield Department of Medicine
Universitat de València
Amsterdam UMC - University of Amsterdam
Giovanni XXIII Hospital
Melbourne Medical School
IRCCS San Martino Polyclinic Hospital
Instituto de Investigación Sanitaria La Fe
Hospital Universitari i Politècnic La Fe
CHU de Nantes
University of Melbourne
Università degli Studi di Genova
Monash University
Hospital Israelita Albert Einstein
Medizinische Universität Wien
Nuffield Department of Medicine
Universitat de València
Amsterdam UMC - University of Amsterdam
Giovanni XXIII Hospital
Corresponding Author(s)
Other Contributor(s)
Abstract
Introduction: Ventilator settings and ventilation variables and parameters vary between neurocritical care and non-neurocritical care patients. We aim to compare ventilation management in neurocritical care patients versus non-neurocritical care patients under invasive mechanical ventilation support, and to determine which factors related to ventilatory management have an independent association with outcome in neurocritical patients. Methods and analysis: We meta-analyze harmonized individual patient data from 3 observational studies (PRactice of VENTilation in critically ill patients without ARDS [PRoVENT], PRactice of VENTilation in critically ill patients in Middle-income Countries [PRoVENT-iMiC] and Extubation strategies and in neuro-intensive care unit patients and associations with outcomes [ENIO]), pooled into a database named PRIME. The primary endpoint is all cause ICU mortality. Secondary endpoints are key ventilator settings and ventilation variables and parameters. To identify potentially modifiable and non-modifiable factors contributing to ICU mortality, a multivariable model will be built using demographic factors, comorbidities, illness severities, and respiratory and laboratorial variables. In analyses examining the impact of ventilatory variables on outcome, we will estimate the relative risk of ICU mortality for neurocritical and non-neurocritical care patients by dividing the study population based on key ventilator variables and parameters. Ethics and dissemination: This meta-analysis will address a clinically significant research question by comparing neurocritical care with non-neurocritical care patients. As this is a meta-analysis, additional ethical committee approval is not required. Findings will be disseminated to the scientific community through abstracts and original articles in peer-reviewed journals. Furthermore, the PRIME database will be made accessible for further post-hoc analyses. Registration: PRoVENT, PRoVENT-iMiC and ENIO, and the pooled database PRIME are registered at clinicaltrials.gov (NCT01868321 for PRoVENT, NCT03188770 for PRoVENT-iMiC, and NCT03400904 for ENIO, and for PRIME is pending).
