Validation Calibration Factor of Single Photon Emission Computed Tomography for Iodine-131 using Non-Spherical Targeted Volume
Issued Date
2023-01-01
Resource Type
eISSN
22897895
Scopus ID
2-s2.0-85180455321
Journal Title
Journal of Advanced Research in Applied Mechanics
Volume
110
Issue
1
Start Page
73
End Page
85
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Advanced Research in Applied Mechanics Vol.110 No.1 (2023) , 73-85
Suggested Citation
Masud M.A., Ngali M.Z., Othman S.A., Taib I., Osman K., Salleh S.M., Khudzari A.Z.M., Ali N.S., Chaichana A. Validation Calibration Factor of Single Photon Emission Computed Tomography for Iodine-131 using Non-Spherical Targeted Volume. Journal of Advanced Research in Applied Mechanics Vol.110 No.1 (2023) , 73-85. 85. doi:10.37934/aram.110.1.7385 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/95899
Title
Validation Calibration Factor of Single Photon Emission Computed Tomography for Iodine-131 using Non-Spherical Targeted Volume
Corresponding Author(s)
Other Contributor(s)
Abstract
Absolute quantification of Iodine-131 (131I) on Single Photon Emission Computed Tomography (SPECT) imaging is extremely necessary for the lesion dose per administrative differentiated thyroid cancer procedure. However, non-quantitative SPECT imaging makes determining the dose required for a tumour to be treated is challenging. This multi-vendor and multi-centre research use phantom measures to assess the quantitative accuracy and inter-system variability of various SPECT/CT systems. Hence, this study aims to determine the calibration factor (CF) for131I activity quantification using the National Electrical Manufacturer Association (NEMA) phantom uptake for the Philips BrightView XCT modality. The accuracy activity concentration for a non-spherical targeted volume is less than 15% compared to a spherical targeted volume (<9%). Furthermore, the CF has no significant difference in the value between the matrix sizes of 64×64, 128×128, and 256×256. Therefore, the gamma camera CF must be precisely determined to convert the reconstructed images' counts into activity values for quantitative imaging. However, the NEMA phantom with spherical geometrical is the standard tool for determining CF, the various geometrical shapes other than spherical should be considered for determining CF because the effect of photon distribution contribution is different for any different lesion geometrical.