Increased tissue expression of IL-31 in patients with psoriasis
Issued Date
2024-04-01
Resource Type
ISSN
10434666
eISSN
10960023
Scopus ID
2-s2.0-85184018588
Journal Title
Cytokine
Volume
176
Rights Holder(s)
SCOPUS
Bibliographic Citation
Cytokine Vol.176 (2024)
Suggested Citation
Wongjirattikarn R., Chaisuriya N., Chaowattanapanit S., Ungarreevittaya P., Poosekeaw P., Winaikosol K., Choonhakarn C., Julanon N., Utchariyaprasit E., Sawanyawisuth K. Increased tissue expression of IL-31 in patients with psoriasis. Cytokine Vol.176 (2024). doi:10.1016/j.cyto.2024.156531 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97142
Title
Increased tissue expression of IL-31 in patients with psoriasis
Author's Affiliation
Corresponding Author(s)
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Abstract
Psoriasis is a chronic inflammatory skin disease, and its pathogenesis remains unclear. Although many studies have demonstrated the role of serum interleukin-31 (IL-31) in psoriasis, only one study has examined histopathological expression in lesional skin. This study aimed to investigate the expression of IL-31 in skin biopsy specimens of psoriasis patients compared to healthy subjects and identify its possible correlation to disease severity and itch intensity. Psoriasis patients and healthy volunteers were recruited. Four-millimeter punch biopsy was performed at the lesional skin of psoriasis patients and normal skin of healthy subjects. Expression of IL-31 was measured by immunohistochemistry. Baseline characteristics, disease activity, itch intensity, and related laboratory results were collected. Twenty-six biopsy specimens of psoriasis patients and 10 tissue samples of healthy subjects were evaluated. Epidermal and dermal psoriasis lesions had significantly higher IL-31 expression compared to the healthy skin (P < 0.001). However, there was no significant difference in lesional expression of IL-31 by disease severity or itch intensity. Increased IL-31 expression in the lesions of psoriasis patients suggests the involvement of IL-31 in the pathogenesis of psoriasis.
