The epidemiology and burden of neuromyelitis optica spectrum disorder, multiple sclerosis, and MOG antibody-associated disease in a province in Thailand: A population-based study
Issued Date
2023-02-01
Resource Type
ISSN
22110348
eISSN
22110356
Scopus ID
2-s2.0-85147128339
Pubmed ID
36640562
Journal Title
Multiple Sclerosis and Related Disorders
Volume
70
Rights Holder(s)
SCOPUS
Bibliographic Citation
Multiple Sclerosis and Related Disorders Vol.70 (2023)
Suggested Citation
Tisavipat N. The epidemiology and burden of neuromyelitis optica spectrum disorder, multiple sclerosis, and MOG antibody-associated disease in a province in Thailand: A population-based study. Multiple Sclerosis and Related Disorders Vol.70 (2023). doi:10.1016/j.msard.2023.104511 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82171
Title
The epidemiology and burden of neuromyelitis optica spectrum disorder, multiple sclerosis, and MOG antibody-associated disease in a province in Thailand: A population-based study
Author(s)
Other Contributor(s)
Abstract
Background: Central nervous system inflammatory demyelinating diseases (CNSIDDs) have notable interracial heterogeneity. The epidemiology of CNSIDDs in Thailand, a mainland Southeast Asian country, is unknown. Objectives: To determine the cumulative incidence, point prevalence, and disease burden of neuromyelitis optica spectrum disorder (NMOSD) and other CNSIDDs in Thailand using population-based data of Chumphon. Methods: Searching for CNSIDD patients at a public secondary care hospital in Chumphon, the only neurology center in the province, from January 2016 to December 2021 was implemented using relevant ICD-10-CM codes. All diagnoses were individually ascertained by a retrospective chart review. Cumulative incidence, point prevalence, attack rate, mortality rate, and disability-adjusted life years (DALYs) were calculated. Results: Aquaporin 4-IgG-positive NMOSD was the most prevalent CNSIDD in the Thai population at 3.08 (1.76–5.38) per 100,000 persons. The prevalence of multiple sclerosis (MS) followed at 0.77 (0.26–2.26) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) at 0.51(0.14–1.87) per 100,000 adults. In the pediatric population, the incidence of acute disseminated encephalomyelitis was 0.28 (0.08–1.02) per 100,000 persons/year. Among other idiopathic demyelinating diseases, idiopathic optic neuritis had the highest incidence at 0.58 (0.24–0.92) per 100,000 persons/year, followed by acute transverse myelitis at 0.44 (0.14–0.74). Idiopathic demyelinating brainstem syndrome was also observed at 0.04 (0.01–0.25) per 100,000 persons/year. Although most had a fair recovery, disability was worst among NMOSD patients with DALYs of 3.61 (3.00–4.36) years per 100,000 persons. Mortality rate was the highest in NMOSD as well. Conclusion: CNSIDDs are rare diseases in Thailand. The prevalence is comparable to that of East Asian populations. A nationwide CNSIDDs registry would better elaborate the epidemiology of these diseases.