Comparison of maternal characteristics and clinical parameters in Thai pregnant women with and without gestational diabetes mellitus
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Issued Date
2025-08-01
Resource Type
ISSN
01688227
eISSN
18728227
Scopus ID
2-s2.0-105008674395
Journal Title
Diabetes Research and Clinical Practice
Volume
226
Rights Holder(s)
SCOPUS
Bibliographic Citation
Diabetes Research and Clinical Practice Vol.226 (2025)
Suggested Citation
Hanafee A., Suthon S., Innang S., Songlilitchuwong S., Masuwan N., Narkdontri T., Teerawattanapong N., Boriboonhirunsarn D., Tangjittipokin W. Comparison of maternal characteristics and clinical parameters in Thai pregnant women with and without gestational diabetes mellitus. Diabetes Research and Clinical Practice Vol.226 (2025). doi:10.1016/j.diabres.2025.112336 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110967
Title
Comparison of maternal characteristics and clinical parameters in Thai pregnant women with and without gestational diabetes mellitus
Author's Affiliation
Corresponding Author(s)
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Abstract
Objective: Gestational Diabetes Mellitus (GDM) poses a significant risk to maternal and fetal health, yet remains underrecognized in Southeast Asia, particularly in Thailand. Methods: This retrospective cohort study aimed to compare maternal characteristics and clinical parameters between pregnant women with and without GDM, who attended antenatal care at Siriraj Hospital, Thailand, using the 50-g GCT and 100-g OGTT. Results: A total of 825 pregnant women were included, comprising 141 with GDM and 684 non-GDM controls. Statistical analyses revealed that women with GDM were significantly older, had higher gestational age at diagnosis, higher pre-pregnancy BMI, and elevated systolic and diastolic blood pressures. Family history of diabetes and comorbidities were more prevalent in the GDM group. The laboratory findings showed significant differences in white blood cell counts, particularly in the levels of neutrophils and lymphocytes. Moreover, elevated levels of alanine transaminase and HbA1c were observed in cases of GDM. Finally, diastolic blood pressure (aOR 1.036, 95 % CI 1.008–1.064, p = 0.01) and the presence of comorbidities (aOR 9.027, 95 % CI 5.573–14.621, p < 0.001) were identified as independent risk factors for GDM. Conclusion: These findings underscore distinct clinical and biochemical profiles in Thai women with GDM, emphasizing the need for early detection and targeted interventions to mitigate associated risks.