Hybrid immunity from SARS-CoV-2 infection and mRNA BNT162b2 vaccine among Thai school-aged children
Issued Date
2023-12-01
Resource Type
eISSN
25901362
Scopus ID
2-s2.0-85179061783
Journal Title
Vaccine: X
Volume
15
Rights Holder(s)
SCOPUS
Bibliographic Citation
Vaccine: X Vol.15 (2023)
Suggested Citation
Saraban K., Suntarattiwong P., Chantasrisawad N., Boonsathorn S., Kosalaraksa P., Phongsamart W., Tangsathapornpong A., Jaruampornpan P., Srisarang S., Puthanakit T. Hybrid immunity from SARS-CoV-2 infection and mRNA BNT162b2 vaccine among Thai school-aged children. Vaccine: X Vol.15 (2023). doi:10.1016/j.jvacx.2023.100414 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/91497
Title
Hybrid immunity from SARS-CoV-2 infection and mRNA BNT162b2 vaccine among Thai school-aged children
Author's Affiliation
Siriraj Hospital
Faculty of Medicine, Khon Kaen University
King Chulalongkorn Memorial Hospital
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Faculty of Medicine, Thammasat University
Thailand National Center for Genetic Engineering and Biotechnology
Queen Sirikit National Institute of Child Health
Faculty of Medicine, Chulalongkorn University
Faculty of Medicine, Khon Kaen University
King Chulalongkorn Memorial Hospital
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Faculty of Medicine, Thammasat University
Thailand National Center for Genetic Engineering and Biotechnology
Queen Sirikit National Institute of Child Health
Faculty of Medicine, Chulalongkorn University
Other Contributor(s)
Abstract
Objective: To compare the immune response of hybrid immunity – arising from SARS-CoV-2 infection and mRNA BNT162b2 vaccination – to that of 2-doses of vaccine. Methods: In a subanalysis of BNT162b2 vaccine trial in 5 to 11-year-old children, There were 179 children who had hybrid immunity compared with 134 children with solely 2-dose vaccine. The immunological outcome was a surrogate virus neutralization test (sVNT) against the Omicron strain, BA.1, (%inhibition). An sVNT level ≥68 % inhibition was considered as protective immune response. Results: From February to April 2022, 179 children had COVID-19 natural infection resulting in hybrid immunity included: Group1;prior vaccination(n = 17), Group2;after the first dose(n = 61), and Group3;after the second dose(n = 97). The proportion of children with protective immune response was higher in Group 3 and Group 1 – 61.9 % and 58.8 %, compared to 36.1 % and 34.3 % in Group 2 and comparator group (2 doses of vaccine), respectively. The geometric mean % inhibition of sVNT was higher in Group 1 (68.5, 95 %CI 55.5–84.6) and Group 3 (63.5, 95 %CI 55.5–72.6), followed by comparator group (49.6, 95 %CI 44.8–54.9) and Group 2 (42.1, 95 %CI 34.6–51.3), p < 0.001. Conclusions: Immune response that arises from BNT162b2 vaccine after natural infection and infection after 2 doses of BNT162b2 was higher than infection after partially-vaccinated children.