Combined quality of life and survival for estimation of long-term health outcome of patients with stroke
Issued Date
2022-12-01
Resource Type
eISSN
14777525
Scopus ID
2-s2.0-85127043802
Pubmed ID
35331254
Journal Title
Health and Quality of Life Outcomes
Volume
20
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Health and Quality of Life Outcomes Vol.20 No.1 (2022)
Suggested Citation
Butsing N., Tipayamongkholgul M., Wang J.D., Ratanakorn D. Combined quality of life and survival for estimation of long-term health outcome of patients with stroke. Health and Quality of Life Outcomes Vol.20 No.1 (2022). doi:10.1186/s12955-022-01959-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85332
Title
Combined quality of life and survival for estimation of long-term health outcome of patients with stroke
Author(s)
Other Contributor(s)
Abstract
Background: Advanced medical technologies can prolong life of stroke survivors. Dynamic change of health outcomes provides essential information to manage stroke. Mathematical models, to extrapolate health status over a lifetime from cross-sectional data, can be used to investigate long term health outcomes among stroke survivors. This study aimed to estimate the health outcomes of ischemic stroke (IS) and intracerebral hemorrhage (ICH) at each survival time point. Methods: The cohort of 5391 patients with IS and ICH stroke, registered at Ramathibodi Hospital from 2005 to 2013, were followed up regarding survival status until 2016 with the National Mortality Registry. Survival functions were extrapolated over 50 years to age- and sex-matched referents simulated from the national data of the Thailand National Health Statistic Office. From July to December 2016, the EuroQoL 5-dimension questionnaire was used to measure quality of life (QoL) among 400 consecutive, cross-sectional subsamples. The survival functions were then adjusted by the utility values of QoL for the stroke cohort to estimate quality adjusted life expectancy (QALE). Results: The average health utility values were lower in the initial months, then slowly increased to stable levels. However, male stroke survivors presented higher health utility than females. Throughout lifetime estimation, patients with IS stroke exhibit better health outcomes than those with ICH [10.2 vs. 7.5 quality-adjusted life years (QALYs)]. Patients with ICH presented a significantly decreased QoL than patients with IS (16.3 and 8.5 QALYs). Conclusion: Preventing stroke can save people from reduced years and QoL, which can be quantified by loss-of-QALE in QALY units to compare health benefits from prevention, clinical diagnosis and direct treatment.