Effects of Cannabidiol Oil on Anesthetic Requirements in Cats: MAC Determination and Serum Profiling via Nanoscale Liquid Chromatography–Tandem Mass Spectrometry
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Issued Date
2025-05-01
Resource Type
eISSN
20762615
Scopus ID
2-s2.0-105006501847
Journal Title
Animals
Volume
15
Issue
10
Rights Holder(s)
SCOPUS
Bibliographic Citation
Animals Vol.15 No.10 (2025)
Suggested Citation
Suriyawongpongsa P., Niyom S., Wanapinit K., Vijarnsorn M., Roytrakul S., Ploypetch S. Effects of Cannabidiol Oil on Anesthetic Requirements in Cats: MAC Determination and Serum Profiling via Nanoscale Liquid Chromatography–Tandem Mass Spectrometry. Animals Vol.15 No.10 (2025). doi:10.3390/ani15101393 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110515
Title
Effects of Cannabidiol Oil on Anesthetic Requirements in Cats: MAC Determination and Serum Profiling via Nanoscale Liquid Chromatography–Tandem Mass Spectrometry
Corresponding Author(s)
Other Contributor(s)
Abstract
Cannabidiol (CBD), a non-psychotropic cannabinoid derived from Cannabis plants, is increasingly explored for its potential therapeutic applications in veterinary medicine. This study aimed to evaluate the impact of CBD oil on the minimum alveolar concentration of isoflurane (MAC<inf>iso</inf>) in cats. Sixteen healthy cats underwent isoflurane anesthesia, and the MAC<inf>iso</inf> was determined using the tail-clamping technique both at baseline and 30 min after the administration of CBD oil (2 mg/kg) via a stomach tube. CBD administration resulted in a significant 11% reduction in the MAC<inf>iso</inf>, from 1.77 ± 0.14% to 1.62 ± 0.21% (p < 0.001). Following CBD administration, heart and respiratory rates were elevated at the time of MAC<inf>iso</inf> determination compared to baseline whereas other physiological parameters remained unchanged. Serum biochemical analysis conducted two weeks post administration revealed a significant decrease in blood urea nitrogen (BUN) levels while one cat exhibited a mild increase in alanine aminotransferase (ALT). Proteomic analysis identified 12 CBD-associated proteins in feline serum 30 min post administration, with CBDA and THCA synthases demonstrating significant upregulation. These findings indicate that CBD oil reduces anesthetic requirements in cats without inducing significant physiological disturbances. Further research is warranted to elucidate the underlying mechanisms of CBD’s anesthetic-sparing effects and its implications in veterinary anesthesia.