Rapidly progressive interstitial pneumonia associated with anti-NXP2 antibody secondary to malignancy
Issued Date
2022-01-01
Resource Type
eISSN
22130071
Scopus ID
2-s2.0-85141858148
Journal Title
Respiratory Medicine Case Reports
Volume
40
Rights Holder(s)
SCOPUS
Bibliographic Citation
Respiratory Medicine Case Reports Vol.40 (2022)
Suggested Citation
Wuthithepbuncha N. Rapidly progressive interstitial pneumonia associated with anti-NXP2 antibody secondary to malignancy. Respiratory Medicine Case Reports Vol.40 (2022). doi:10.1016/j.rmcr.2022.101765 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86256
Title
Rapidly progressive interstitial pneumonia associated with anti-NXP2 antibody secondary to malignancy
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
The diagnosis of a diffuse lung disease is challenging for physicians and it requires a multidisciplinary team approach to solve this problem. Herein, we present a case of common bile duct obstruction from pancreatic ductal adenocarcinoma after biliary stent placement, which developed a rapidly progressive bilateral lung infiltration after oesophagogastroduodenoscopy. After a diagnostic evaluation based on clinical, radiographic, and pathological findings, a diagnosis of rapidly progressive interstitial pneumonia associated with anti-nuclear matrix protein (NXP) 2 antibody secondary to malignancy was made. In patients with interstitial lung disease with unclear aetiologies, autoantibodies, including antinuclear antibody and myositis-specific antibodies should be evaluated, even if there are no clinical signs of autoimmune disease. Although this is the first case report of an acute interstitial pneumonitis-associated anti-NXP2 antibody, physicians should recognise this condition as it can rapidly cause acute fulminant respiratory failure.