COVID-19 vaccination-related delayed adverse events among people with rheumatoid arthritis: results from the international COVAD survey
Issued Date
2024-01-01
Resource Type
ISSN
01728172
eISSN
1437160X
Scopus ID
2-s2.0-85208802336
Pubmed ID
39503760
Journal Title
Rheumatology International
Rights Holder(s)
SCOPUS
Bibliographic Citation
Rheumatology International (2024)
Suggested Citation
Dey M., Doskaliuk B., Parodis I., Lindblom J., Wincup C., Joshi M., Dey D., Katchamart W., Kadam E., Sen P., Shinjo S.K., Nune A., Goo P.A., Ziade N., Chen Y.M., Traboco L.S., Gutiérrez C.E.T., Vaidya B., Agarwal V., Gupta L., Nikiphorou E., Arredondo G., Quezada I., Calapaqui W., Idania E.M., Saenz R., Hidalgo E.R., Arrieta D., Sierra-Zorita R., Llerena G.A.R., Ordóñez A.B., Chávez N., Obiols A.Q., Salinas R.G., Pastelin C.B.S., Alonzo H., Báez J.T., Cristian V.M., Nunez L.S., Ho E.J.G., Bautista G.G., Cachafeiro-Vilar A., Colaman N., Losanto J., Cabriza K., Fuentes-Silva Y., Harifi G., Mohammed R.H.A., Fathi H.M., Pimentel V., Bernaola J.P., Chinchay L., Ugarte-Gil M.F., So H., Palalane E., Koussougbo O.D., Becky A., Olaosebikan H., Yerima A., Madu N.H., Airenakho E., Dedeke I., Ima-Edomwonyi U., Bohdana D., Zimba O., Fonseca J.E., Silva J.A.P., Cajas J., Arbeláez Á., Zuleta W.G.R., Landon-Cardinal O., Hudson M., Srivastav N., Needham M., Limaye V., Langguth D., Meyer A., Campagne J., Maurier F., Giannini M., Baba Z., bouchti I., Hmamouchi I., Griger Z., Aharonov O., Gromova M.A., Holzer M.T., Proft F.N., Tomaras S., Gono T., Kaneko Y., Kimura N., Sato S., Nakashima R., Gonzalez R.A., Prieto-González S., Loarce-Martos J., Wibowo S.A.K., Fornaro M., Ioannone F. COVID-19 vaccination-related delayed adverse events among people with rheumatoid arthritis: results from the international COVAD survey. Rheumatology International (2024). doi:10.1007/s00296-024-05742-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/102084
Title
COVID-19 vaccination-related delayed adverse events among people with rheumatoid arthritis: results from the international COVAD survey
Author(s)
Dey M.
Doskaliuk B.
Parodis I.
Lindblom J.
Wincup C.
Joshi M.
Dey D.
Katchamart W.
Kadam E.
Sen P.
Shinjo S.K.
Nune A.
Goo P.A.
Ziade N.
Chen Y.M.
Traboco L.S.
Gutiérrez C.E.T.
Vaidya B.
Agarwal V.
Gupta L.
Nikiphorou E.
Arredondo G.
Quezada I.
Calapaqui W.
Idania E.M.
Saenz R.
Hidalgo E.R.
Arrieta D.
Sierra-Zorita R.
Llerena G.A.R.
Ordóñez A.B.
Chávez N.
Obiols A.Q.
Salinas R.G.
Pastelin C.B.S.
Alonzo H.
Báez J.T.
Cristian V.M.
Nunez L.S.
Ho E.J.G.
Bautista G.G.
Cachafeiro-Vilar A.
Colaman N.
Losanto J.
Cabriza K.
Fuentes-Silva Y.
Harifi G.
Mohammed R.H.A.
Fathi H.M.
Pimentel V.
Bernaola J.P.
Chinchay L.
Ugarte-Gil M.F.
So H.
Palalane E.
Koussougbo O.D.
Becky A.
Olaosebikan H.
Yerima A.
Madu N.H.
Airenakho E.
Dedeke I.
Ima-Edomwonyi U.
Bohdana D.
Zimba O.
Fonseca J.E.
Silva J.A.P.
Cajas J.
Arbeláez Á.
Zuleta W.G.R.
Landon-Cardinal O.
Hudson M.
Srivastav N.
Needham M.
Limaye V.
Langguth D.
Meyer A.
Campagne J.
Maurier F.
Giannini M.
Baba Z.
bouchti I.
Hmamouchi I.
Griger Z.
Aharonov O.
Gromova M.A.
Holzer M.T.
Proft F.N.
Tomaras S.
Gono T.
Kaneko Y.
Kimura N.
Sato S.
Nakashima R.
Gonzalez R.A.
Prieto-González S.
Loarce-Martos J.
Wibowo S.A.K.
Fornaro M.
Ioannone F.
Doskaliuk B.
Parodis I.
Lindblom J.
Wincup C.
Joshi M.
Dey D.
Katchamart W.
Kadam E.
Sen P.
Shinjo S.K.
Nune A.
Goo P.A.
Ziade N.
Chen Y.M.
Traboco L.S.
Gutiérrez C.E.T.
Vaidya B.
Agarwal V.
Gupta L.
Nikiphorou E.
Arredondo G.
Quezada I.
Calapaqui W.
Idania E.M.
Saenz R.
Hidalgo E.R.
Arrieta D.
Sierra-Zorita R.
Llerena G.A.R.
Ordóñez A.B.
Chávez N.
Obiols A.Q.
Salinas R.G.
Pastelin C.B.S.
Alonzo H.
Báez J.T.
Cristian V.M.
Nunez L.S.
Ho E.J.G.
Bautista G.G.
Cachafeiro-Vilar A.
Colaman N.
Losanto J.
Cabriza K.
Fuentes-Silva Y.
Harifi G.
Mohammed R.H.A.
Fathi H.M.
Pimentel V.
Bernaola J.P.
Chinchay L.
Ugarte-Gil M.F.
So H.
Palalane E.
Koussougbo O.D.
Becky A.
Olaosebikan H.
Yerima A.
Madu N.H.
Airenakho E.
Dedeke I.
Ima-Edomwonyi U.
Bohdana D.
Zimba O.
Fonseca J.E.
Silva J.A.P.
Cajas J.
Arbeláez Á.
Zuleta W.G.R.
Landon-Cardinal O.
Hudson M.
Srivastav N.
Needham M.
Limaye V.
Langguth D.
Meyer A.
Campagne J.
Maurier F.
Giannini M.
Baba Z.
bouchti I.
Hmamouchi I.
Griger Z.
Aharonov O.
Gromova M.A.
Holzer M.T.
Proft F.N.
Tomaras S.
Gono T.
Kaneko Y.
Kimura N.
Sato S.
Nakashima R.
Gonzalez R.A.
Prieto-González S.
Loarce-Martos J.
Wibowo S.A.K.
Fornaro M.
Ioannone F.
Author's Affiliation
Faculty of Medicine and Health
Siriraj Hospital
Faculty of Biology, Medicine and Health
Southport and Ormskirk Hospital NHS Trust
Pontificia Universidad Javeriana, Cali
Seth GS Medical College and KEM Hospital
Hôtel-Dieu de France Hospital
Université Saint-Joseph de Beyrouth
Ivano-Frankivsk National Medical University
Sanjay Gandhi Postgraduate Institute of Medical Sciences
King's College Hospital
Karolinska Universitetssjukhuset
University of Ghana
King's College London
Maulana Azad Medical College
Universidade de São Paulo
The Royal Wolverhampton NHS Trust
Veterans General Hospital-Taichung Taiwan
Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals
St. Luke's Medical Center- Global City
National Center for Rheumatic Diseases
Queen Savang Vadhana Memorial Hospital
Siriraj Hospital
Faculty of Biology, Medicine and Health
Southport and Ormskirk Hospital NHS Trust
Pontificia Universidad Javeriana, Cali
Seth GS Medical College and KEM Hospital
Hôtel-Dieu de France Hospital
Université Saint-Joseph de Beyrouth
Ivano-Frankivsk National Medical University
Sanjay Gandhi Postgraduate Institute of Medical Sciences
King's College Hospital
Karolinska Universitetssjukhuset
University of Ghana
King's College London
Maulana Azad Medical College
Universidade de São Paulo
The Royal Wolverhampton NHS Trust
Veterans General Hospital-Taichung Taiwan
Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals
St. Luke's Medical Center- Global City
National Center for Rheumatic Diseases
Queen Savang Vadhana Memorial Hospital
Corresponding Author(s)
Other Contributor(s)
Abstract
This study aimed to assess COVID-19 vaccination-related AEs in patients with rheumatoid arthritis (RA), in the COVID-19 Vaccination in Autoimmune Diseases (COVAD)-2 study. An online international cross-sectional survey captured self-reported data on COVID-19 vaccination-related adverse events (AEs) in people with RA, autoimmune diseases (AIDs; rheumatic [r] and non-rheumatic [nr]) and healthy controls (HCs). The survey was circulated by the COVAD study group, comprising 157 collaborators across 106 countries, from February to June 2022. Delayed AEs among RA were compared with other rAIDs, nrAIDs and HCs using multivariable binary regression. A total of 7203 participants were included (1423 [19.7%] RA, 2620 [36.4%] rAIDs, 426 [5.9%] nrAIDs, 2734 [38%] HCs), with 75% female. Compared to HCs, individuals with RA reported higher overall major AEs [OR 1.3 (1.0–1.7)], and an increased number of several minor AEs. Compared to nrAIDs, people with RA had several increased reported minor AEs including myalgia and joint pain. People with active RA had increased major AEs [OR 1.8 (1.1–3.0)] and hospitalisation [OR 4.1 (1.3 – 13.3)] compared to inactive RA. RA patients without autoimmune comorbidities had significantly fewer major and minor AEs than those with other rAIDs. A decreased incidence of hospitalisation was seen in patients taking methotrexate or TNF inhibitors compared to patients not taking these medications. COVID-19 vaccination is associated with minimal to no risks of delayed AEs in patients with RA compared to HCs, and fewer compared to other rAIDs. Active RA and presence of co-existing rAIDs were associated with an increased risk of delayed AEs.