The glucose-lowering effect of low-dose diacerein and its responsiveness metabolic markers in uncontrolled diabetes
Issued Date
2022-12-01
Resource Type
eISSN
17560500
Scopus ID
2-s2.0-85125784189
Pubmed ID
35246243
Journal Title
BMC Research Notes
Volume
15
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
BMC Research Notes Vol.15 No.1 (2022)
Suggested Citation
Jangsiripornpakorn J., Srisuk S., Chailurkit L., Nimitphong H., Saetung S., Ongphiphadhanakul B. The glucose-lowering effect of low-dose diacerein and its responsiveness metabolic markers in uncontrolled diabetes. BMC Research Notes Vol.15 No.1 (2022). doi:10.1186/s13104-022-05974-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/83548
Title
The glucose-lowering effect of low-dose diacerein and its responsiveness metabolic markers in uncontrolled diabetes
Other Contributor(s)
Abstract
Objective: Diacerein inhibits the synthesis and activity of pro-inflammatory cytokines, decreases macrophage infiltration in adipose tissue and thus increases insulin sensitivity and signalling. We conducted this study to determine the efficacy of low-dose diacerein in improving glycaemic control in type 2 diabetes mellitus (T2DM) patients with inadequate glycaemic control and to identify the metabolic determinants for such improvement. We randomised 25 T2DM patients with poor glycaemic control, despite being treated with at least three glucose-lowering agents, to receive diacerein 50 mg once-daily (n = 18) or placebo (n = 17) for 12 weeks. Changes in glycated haemoglobin (HbA1c) were evaluated at the 4th and 12th weeks. Metabolic profiling was performed using liquid chromatography electrospray ionisation quadrupole time-of-flight mass spectrometry. Results: HbA1c levels were significantly reduced from baseline in the diacerein group at 12 weeks (− 0.6%, p < 0.05), whereas fasting plasma glucose (FPG) levels were not significantly decreased (− 18.9 mg/dl, p = 0.06). Partial least squares-discriminant analysis demonstrated an association between the serum abundance of threo-isocitric acid (ICA) and HbA1c response in the diacerein group. After adjusting for serum high-sensitivity C-reactive protein, ICA was still significantly related to the change in HbA1c. Retrospective trial registration Current Controlled Trials TCTR20200820004, 20 August 2020.