More than a Bubble: Extracellular Vesicle microRNAs in Head and Neck Squamous Cell Carcinoma
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Issued Date
2022-03-01
Resource Type
eISSN
20726694
Scopus ID
2-s2.0-85125201930
Journal Title
Cancers
Volume
14
Issue
5
Rights Holder(s)
SCOPUS
Bibliographic Citation
Cancers Vol.14 No.5 (2022)
Suggested Citation
Panvongsa W., Pegtel D.M., Voortman J. More than a Bubble: Extracellular Vesicle microRNAs in Head and Neck Squamous Cell Carcinoma. Cancers Vol.14 No.5 (2022). doi:10.3390/cancers14051160 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/86073
Title
More than a Bubble: Extracellular Vesicle microRNAs in Head and Neck Squamous Cell Carcinoma
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that play a pivotal regulatory role in a broad variety of biological processes. Dysregulation of miRNAs is associated with several human diseases, particularly cancer. Extracellular vesicles (EVs) are crucial components in intercellular communication. As part of the cargo of EVs, miRNAs are involved in EV-mediated cell-to-cell interactions, including promotion or suppression of tumor development. The knowledge on the molecular mechanisms and clinical importance of EV-miRNAs in head and neck squamous cell carcinoma (HNSCC) has rapidly grown over the past years. In the present review, the current understanding regarding the effect of EV-miRNAs on HNSCC tumorigenesis is summarized, which includes effects on tumor proliferation, angiogenesis, invasion and metastasis, the tumor microenvironment, immune modulation, and treatment resistance. EV-miRNA-based biomarkers in liquid biopsies such as blood and saliva may open up new possibilities for employing EV-miRNAs for screening and early diagnostics as well as disease monitoring. Future perspectives include the promise of EV-miRNAs as a novel therapeutic target.