Exploring intermittent pneumatic compression parameters to optimize venous peak velocity and flow duration
3
Issued Date
2026-12-01
Resource Type
eISSN
20452322
Scopus ID
2-s2.0-105040561422
Journal Title
Scientific Reports
Volume
16
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scientific Reports Vol.16 No.1 (2026)
Suggested Citation
Homdee N., Supachatwong C., Srisantithum B., Jarungvittayakon C. Exploring intermittent pneumatic compression parameters to optimize venous peak velocity and flow duration. Scientific Reports Vol.16 No.1 (2026). doi:10.1038/s41598-026-47712-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/117140
Title
Exploring intermittent pneumatic compression parameters to optimize venous peak velocity and flow duration
Corresponding Author(s)
Other Contributor(s)
Abstract
Deep vein thrombosis (DVT) is a significant risk in patients with prolonged immobility. Intermittent pneumatic compression devices (IPCDs) are recommended for DVT prevention, yet optimal compression parameters remain poorly defined. This proof-of-concept pilot study evaluated the hemodynamic impact of varying IPCD compression pressures and sequences in healthy volunteers simulating lower-limb immobilization, using a programmable prototype with adjustable settings. Twelve participants underwent continuous Doppler ultrasound measurement of peak systolic velocity (PSV) in the common femoral vein during three compression modes: simultaneous 30 mmHg, simultaneous 50 mmHg, and sequential 30 mmHg. All modes significantly increased PSV compared to resting baseline (per-participant means, n = 12, paired t-tests). Simultaneous 30 mmHg produced the highest and most consistent augmentation (mean PSV 40.06 ± 1.53 cm/s; 90% increase from baseline; t(11) = 29.1, p < 0.0001, Cohen’s d = 8.39). Simultaneous 50 mmHg showed significant but more variable augmentation (30.45 ± 6.33 cm/s; t(11) = 4.26, p = 0.001), with a dipping phenomenon in five participants consistent with possible venous occlusion at higher pressures. Sequential 30 mmHg produced the longest augmented flow duration (mean 4.49 s versus 1.85 s for simultaneous 30 mmHg), suggesting greater total venous volume displacement despite lower peak velocity. These findings provide a hemodynamic foundation for IPCD parameter optimization, with clinical validation in patient populations required before implementation.