1,2,3-TRIAZOLE SCAFFOLD IN RECENT MEDICINAL APPLICATIONS: SYNTHESIS AND ANTICANCER POTENTIALS
8
Issued Date
2022-01-01
Resource Type
ISSN
03855414
eISSN
18810942
Scopus ID
2-s2.0-85133858410
Journal Title
Heterocycles
Volume
105
Issue
1
Start Page
147
End Page
178
Rights Holder(s)
SCOPUS
Bibliographic Citation
Heterocycles Vol.105 No.1 (2022) , 147-178
Suggested Citation
Choomuenwai V., Leechaisit R., Pingaew R., Prachayasittikul V., Prachayasittikul S., Prachayasittikul V. 1,2,3-TRIAZOLE SCAFFOLD IN RECENT MEDICINAL APPLICATIONS: SYNTHESIS AND ANTICANCER POTENTIALS. Heterocycles Vol.105 No.1 (2022) , 147-178. 178. doi:10.3987/REV-22-SR(R)4 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/84217
Title
1,2,3-TRIAZOLE SCAFFOLD IN RECENT MEDICINAL APPLICATIONS: SYNTHESIS AND ANTICANCER POTENTIALS
Author's Affiliation
Other Contributor(s)
Abstract
Cancer is one of commonly concerned health problems globally and its management is challenging. Besides an availability of diverse classes of anticancer agents, the existing drugs are noted for their limitations such as considerable toxicities, low potency and responsiveness, drug resistance, and others. 1,2,3-Triazole is an attractive heterocyclic scaffold possessing considerable characteristics and is presented in many pharmacologically active molecules. Accordingly, attention has been given to this scaffold in the recent years, especially, in an area of anticancer drug development. In this review, a collection of recently reported triazole based anticancer agents are discussed along with their synthetic methods, proposed molecular targets, and mechanisms of actions. A summary of other recently reported biological activities is also provided. In overview, recent studies suggested that the 1,2,3-triazole based compounds could elicit their anticancer effects against several cancer cell lines via an inhibition of cancer cell growth, an induction of apoptosis, an inhibition of involved enzymes such as aromatase, kinases, and others. Some interesting results from computational studies also discussed relating to the predictions of possible molecular targets. In summary, it is suggested that the 1,2,3-triazole serves as a potential scaffold with noteworthy opportunity for future development of novel anticancer agents to cope with current challenging issues in cancer management.