Reduced Long-Term Survival After Postoperative Complications in Major Gastrointestinal Surgery
Issued Date
2025-01-01
Resource Type
ISSN
11766336
eISSN
1178203X
Scopus ID
2-s2.0-105018788379
Journal Title
Therapeutics and Clinical Risk Management
Volume
21
Start Page
1459
End Page
1472
Rights Holder(s)
SCOPUS
Bibliographic Citation
Therapeutics and Clinical Risk Management Vol.21 (2025) , 1459-1472
Suggested Citation
Gratama D.N., Weinberg L., Raykateeraroj N., Suh J.M.A., Zhao J., Hu E.P., Ratnasekara V., Freeman T., Liu D.S., Joosten A., Muralidharan V., Nikfarjam M., Lee D.K. Reduced Long-Term Survival After Postoperative Complications in Major Gastrointestinal Surgery. Therapeutics and Clinical Risk Management Vol.21 (2025) , 1459-1472. 1472. doi:10.2147/TCRM.S543913 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/112691
Title
Reduced Long-Term Survival After Postoperative Complications in Major Gastrointestinal Surgery
Corresponding Author(s)
Other Contributor(s)
Abstract
Purpose: We primarily evaluated the relationship between postoperative complications and long-term survival in patients undergoing major gastrointestinal surgery. Secondarily, we investigated the relationship between the severity and the number of complications and long-term survival. While postoperative complications are prevalent after major abdominal surgery and associated with increased mortality, the effect of their severity and accumulation remains insufficiently explored. Patients and Methods: 1989 adult patients undergoing major gastrointestinal surgery between July 2010 and April 2022 were retrospectively studied. Complications were classified using the Clavien-Dindo system. Kaplan-Meier analysis assessed long-term survival, Cox proportional hazards regression with time-dependent coefficients evaluated the impact of complications on mortality. Results: Median age was 64 years (IQR 53–74); 41.8% female and 63.0% of patients were diagnosed with malignancy. Elective procedures comprised 73.0% of cases. Complications occurred in 74.6% of patients. Mortality was higher in patients with complications (32.0%, 95% CI 29.7%-34.5%), compared to those without (21.7%, 95% CI 18.3–25.6%; P<0.001). Severe complications (Clavien-Dindo Grade ≥III) were associated with a 15.01-fold higher hazard of mortality within 18 months postoperatively (95% CI 6.83–33.0; P<0.001). Conclusion: Postoperative complications significantly reduce long-term survival following major gastrointestinal surgery. Both their severity and frequency are critical determinants of poorer outcomes, emphasizing the need for effective prevention strategies.