Rab Proteins as Potential Therapeutic Targets Applied to Crustacean Aquaculture: Rab7 Case Analysis
Issued Date
2025-01-01
Resource Type
ISSN
17535123
eISSN
17535131
Scopus ID
2-s2.0-85215321291
Journal Title
Reviews in Aquaculture
Volume
17
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Reviews in Aquaculture Vol.17 No.1 (2025)
Suggested Citation
Fajardo C., De Donato M., Charoonnart P., Saksmerprome V., Jackson H.O., Mancera J.M., Costas B. Rab Proteins as Potential Therapeutic Targets Applied to Crustacean Aquaculture: Rab7 Case Analysis. Reviews in Aquaculture Vol.17 No.1 (2025). doi:10.1111/raq.13005 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/103023
Title
Rab Proteins as Potential Therapeutic Targets Applied to Crustacean Aquaculture: Rab7 Case Analysis
Author's Affiliation
Faculty of Science, Mahidol University
Tecnológico de Monterrey, Querétaro
University College London
Universidad de Cádiz
CIIMAR - Interdisciplinary Centre of Marine and Environmental Research
Thailand National Center for Genetic Engineering and Biotechnology
Universidade do Porto
Center for Aquaculture Technologies
Tecnológico de Monterrey, Querétaro
University College London
Universidad de Cádiz
CIIMAR - Interdisciplinary Centre of Marine and Environmental Research
Thailand National Center for Genetic Engineering and Biotechnology
Universidade do Porto
Center for Aquaculture Technologies
Corresponding Author(s)
Other Contributor(s)
Abstract
Rab proteins constitute an important subfamily of molecular effectors whose function is related to the modulation of several important cellular and metabolic processes, including controlling intracellular endocytic vesicle trafficking, phagosome formation, endosome maturation, and innate immunity. In crustaceans, the study and characterization of these proteins have garnered great interest, mainly due to their pivotal role in the innate immune response mechanisms against infections. Among the Rab family, the Rab7 stands out as a prominent example of the potential of these proteins as therapeutic targets for the development of genetic therapies to control viral pathogens in crustacean aquaculture. In this review, a compendium of the information currently available in relation to Rab proteins in crustaceans is made, taking the Rab7 protein as a model, emphasizing not only its general aspects of functioning at the molecular level, but also describing in-depth both mechanisms of action and potential interactions, as well as its implications in relation to the immune system, particularly in shrimp.