Recyclable Iron Oxide Loaded Poly (Methyl Methacrylate) Core/Polyethyleneimine Shell Nanoparticle as Antimicrobial Nanomaterial for Zoonotic Pathogen Controls
Issued Date
2022-03-01
Resource Type
ISSN
10407278
eISSN
15728862
Scopus ID
2-s2.0-85099909781
Journal Title
Journal of Cluster Science
Volume
33
Issue
2
Start Page
567
End Page
577
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Cluster Science Vol.33 No.2 (2022) , 567-577
Suggested Citation
Pimpha N., Woramongkolchai N., Sunintaboon P., Saengkrit N. Recyclable Iron Oxide Loaded Poly (Methyl Methacrylate) Core/Polyethyleneimine Shell Nanoparticle as Antimicrobial Nanomaterial for Zoonotic Pathogen Controls. Journal of Cluster Science Vol.33 No.2 (2022) , 567-577. 577. doi:10.1007/s10876-021-01990-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/83817
Title
Recyclable Iron Oxide Loaded Poly (Methyl Methacrylate) Core/Polyethyleneimine Shell Nanoparticle as Antimicrobial Nanomaterial for Zoonotic Pathogen Controls
Author's Affiliation
Other Contributor(s)
Abstract
In this study, a recyclable antimicrobial agent against infectious pathogens in contaminated water was proposed. Iron oxide (IO) loaded poly (methyl methacrylate) (PMMA) core/polyethyleneimine (PEI) shell nanoparticles (PMMA/PEI-IO) was fabricated. The PMMA/PEI-IO showed a cationic surface charge property which is reflected by the protonation behavior of PEI. IO content in PMMA/PEI was evaluated by TGA and indicated that the residue incorporation of IO was 50% by dried weight. The existing of IO in PMMA/PEI was confirmed by the vibrating-sample magnetometer (VSM) showing a superparamagnetic property. The antibacterial ability was confirmed in waterborne bacteria, Escherichia coli and Staphylococcus aureus. The disturbance of the cell membrane integrity occurred after 20 min post-incubation of PMMA/PEI-IO with bacteria. Antimicrobial activity and recycling ability was further confirmed in an infectious, zoonotic and waterborne pathogen, Streptococcus agalactiae. Antiviral activity of PMMA/PEI-IO was observed and proved in an avian flu virus H3N2, a virus that has the potential to contaminate water reservoirs. The result showed that PMMA/PEI-IO nanoparticles were effective in killing H3N2. This study proposes a novel nanoparticle-based antimicrobial agents with recycle ability. Moreover, PMMA/PEI-IO nanoparticle is a potent bactericidal and virucidal agents when tested with waterborn zoonotic pathogens.