Pregnancy- and birth-related risk factors for the development of childhood celiac disease
Issued Date
2023-05-01
Resource Type
ISSN
08035253
eISSN
16512227
Scopus ID
2-s2.0-85147528373
Pubmed ID
36708080
Journal Title
Acta Paediatrica, International Journal of Paediatrics
Volume
112
Issue
5
Start Page
1029
End Page
1034
Rights Holder(s)
SCOPUS
Bibliographic Citation
Acta Paediatrica, International Journal of Paediatrics Vol.112 No.5 (2023) , 1029-1034
Suggested Citation
Tanpowpong P., Li S., Espinola J.A., Santos L.C., James K.E., Powe C.E., Camargo C.A. Pregnancy- and birth-related risk factors for the development of childhood celiac disease. Acta Paediatrica, International Journal of Paediatrics Vol.112 No.5 (2023) , 1029-1034. 1034. doi:10.1111/apa.16686 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82059
Title
Pregnancy- and birth-related risk factors for the development of childhood celiac disease
Other Contributor(s)
Abstract
Aim: To evaluate whether pregnancy and birth-related factors are associated with celiac disease (CD) in a large, United States (US)-based mother-child cohort. Methods: We analysed data gathering from the Massachusetts General Hospital Maternal Child Cohort (MMCC) of children born between 1998 and 2016. Data included the mode of delivery, maternal pregnancy and their offspring characteristics. We searched for CD cases by using diagnosis billing codes. Cox proportional hazard regression models were created to identify variables associated with CD. Results: We identified 44 539 mother-child pairs who had at least one encounter by 5 years old and identified 173 children (0.4%) with CD diagnosis; median age at the diagnosis was 6 years. Overall, the adjusted hazard ratio (aHR) of caesarean delivery for CD was 1.39 (95% CI: 0.99, 1.96, p = 0.06) when compared to children born vaginally. After stratifying for the presence of labour, children born by Caesarean delivery without labour had a higher risk of CD (aHR 1.56; 95%CI: 1.01, 2.41; p = 0.046) while infants born by Caesarean delivery with labour did not (aHR 1.26; 95% CI: 0.83, 1.93; p = 0.28). Conclusion: Being born by Caesarean delivery without labour may be associated with an increased risk for CD in the US children.