Systematic comparison of HIV-1 Envelope-specific IgG responses induced by different vaccination regimens: Can we steer IgG recognition towards regions of viral vulnerability?
Issued Date
2023-01-09
Resource Type
eISSN
16643224
Scopus ID
2-s2.0-85147214727
Pubmed ID
36741409
Journal Title
Frontiers in Immunology
Volume
13
Rights Holder(s)
SCOPUS
Bibliographic Citation
Frontiers in Immunology Vol.13 (2023)
Suggested Citation
Horvath A., Rogers L., Pollakis G., Baranov O., Pieroth N., Joseph S., Chachage M., Heitzer A., Maganga L., Msafiri F., Joachim A., Viegas E., Eller L.A., Kibuuka H., Rerks-Ngarm S., Pitisuttithum P., Nitayapan S., Dhitavat J., Premsri N., Fidler S., Shattock R.J., Robb M.L., Weber J., McCormack S., Munseri P.J., Lyamuya E., Nilsson C., Kroidl A., Hoelscher M., Wagner R., Geldmacher C., Held K. Systematic comparison of HIV-1 Envelope-specific IgG responses induced by different vaccination regimens: Can we steer IgG recognition towards regions of viral vulnerability?. Frontiers in Immunology Vol.13 (2023). doi:10.3389/fimmu.2022.1075606 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/81951
Title
Systematic comparison of HIV-1 Envelope-specific IgG responses induced by different vaccination regimens: Can we steer IgG recognition towards regions of viral vulnerability?
Author(s)
Horvath A.
Rogers L.
Pollakis G.
Baranov O.
Pieroth N.
Joseph S.
Chachage M.
Heitzer A.
Maganga L.
Msafiri F.
Joachim A.
Viegas E.
Eller L.A.
Kibuuka H.
Rerks-Ngarm S.
Pitisuttithum P.
Nitayapan S.
Dhitavat J.
Premsri N.
Fidler S.
Shattock R.J.
Robb M.L.
Weber J.
McCormack S.
Munseri P.J.
Lyamuya E.
Nilsson C.
Kroidl A.
Hoelscher M.
Wagner R.
Geldmacher C.
Held K.
Rogers L.
Pollakis G.
Baranov O.
Pieroth N.
Joseph S.
Chachage M.
Heitzer A.
Maganga L.
Msafiri F.
Joachim A.
Viegas E.
Eller L.A.
Kibuuka H.
Rerks-Ngarm S.
Pitisuttithum P.
Nitayapan S.
Dhitavat J.
Premsri N.
Fidler S.
Shattock R.J.
Robb M.L.
Weber J.
McCormack S.
Munseri P.J.
Lyamuya E.
Nilsson C.
Kroidl A.
Hoelscher M.
Wagner R.
Geldmacher C.
Held K.
Author's Affiliation
Faculty of Tropical Medicine, Mahidol University
Public Health Agency of Sweden
Muhimbili University of Health and Allied Sciences
Instituto Nacional de Saude Maputo
Makerere University
National Institute for Medical Research Tanga
Universität Regensburg
University College London
University of Liverpool
Imperial College Faculty of Medicine
Klinikum der Universität Regensburg und Medizinische Fakultät
Armed Forces Research Institute of Medical Sciences, Thailand
Thailand Ministry of Public Health
Karolinska Institutet
Klinikum der Universität München
Partner Site Munich
Advancement of Military Medicine, Inc.
Military HIV Research Program
Public Health Agency of Sweden
Muhimbili University of Health and Allied Sciences
Instituto Nacional de Saude Maputo
Makerere University
National Institute for Medical Research Tanga
Universität Regensburg
University College London
University of Liverpool
Imperial College Faculty of Medicine
Klinikum der Universität Regensburg und Medizinische Fakultät
Armed Forces Research Institute of Medical Sciences, Thailand
Thailand Ministry of Public Health
Karolinska Institutet
Klinikum der Universität München
Partner Site Munich
Advancement of Military Medicine, Inc.
Military HIV Research Program
Other Contributor(s)
Abstract
Immunogens and vaccination regimens can influence patterns of immune-epitope recognition, steering them towards or away from epitopes of potential viral vulnerability. HIV-1 envelope (Env)-specific antibodies targeting variable region 2 (V2) or 3 (V3) correlated with protection during the RV144 trial, however, it was suggested that the immunodominant V3 region might divert antibody responses away from other relevant sites. We mapped IgG responses against linear Env epitopes in five clinical HIV vaccine trials, revealing a specific pattern of Env targeting for each regimen. Notable V2 responses were only induced in trials administering CRF01_AE based immunogens, but targeting of V3 was seen in all trials, with the soluble, trimeric CN54gp140 protein eliciting robust V3 recognition. Strong V3 targeting was linked to greater overall response, increased number of total recognised antigenic regions, and where present, stronger V2 recognition. Hence, strong induction of V3-specific antibodies did not negatively impact the targeting of other linear epitopes in this study, suggesting that the induction of antibodies against V3 and other regions of potential viral vulnerability need not be necessarily mutually exclusive.