Codon usage of human DNA viruses and its similarity to certain host genes
Issued Date
2025-12-01
Resource Type
eISSN
20452322
Scopus ID
2-s2.0-105023453214
Pubmed ID
41326434
Journal Title
Scientific Reports
Volume
15
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scientific Reports Vol.15 No.1 (2025)
Suggested Citation
Sirihongthong T., Jitobaom K., Boonarkart C., sheerazi K., Auewarakul P. Codon usage of human DNA viruses and its similarity to certain host genes. Scientific Reports Vol.15 No.1 (2025). doi:10.1038/s41598-025-27070-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/113432
Title
Codon usage of human DNA viruses and its similarity to certain host genes
Author's Affiliation
Corresponding Author(s)
Other Contributor(s)
Abstract
Codon usages of DNA viruses had previously been shown to associate with their genome size. Codon usage of various human DNA viruses was compared to those of human genes to further understand viral codon usage and its roles in viral-host interaction. Codon usage bias in both large and small genome human DNA viruses was dominantly driven by translation selection. Non-optimal codon usage in small DNA viruses showed similarity to cell cycle-related genes, whereas codon usage of large DNA viruses was more diverse, herpesviruses showed more heterogeneity than human adenoviruses, while poxviruses showed a clear bimodal pattern. Some of the large DNA viruses such as herpes simplex and molluscum contagiosum viruses showed more optimal codon usage. Enrichment analysis identified some groups of human genes with similar codon usage to each group of these viruses. These host genes with similarity in codon usages to those of viruses may be efficiently expressed in infected cells and involved in their life cycle, pathogenesis and/or immune evasion.