Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance
Issued Date
2024-12-01
Resource Type
eISSN
20411723
Scopus ID
2-s2.0-85213796882
Journal Title
Nature Communications
Volume
15
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nature Communications Vol.15 No.1 (2024)
Suggested Citation
Ngwana-Joseph G.C., Phelan J.E., Manko E., Dombrowski J.G., da Silva Santos S., Suarez-Mutis M., Vélez-Tobón G., Tobón Castaño A., Machado R.L.D., Marinho C.R.F., Nolder D., Nosten F., Sutherland C.J., Campino S., Clark T.G. Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance. Nature Communications Vol.15 No.1 (2024). doi:10.1038/s41467-024-54964-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/102655
Title
Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance
Corresponding Author(s)
Other Contributor(s)
Abstract
Increasing reports of chloroquine resistance (CQR) in Plasmodium vivax endemic regions have led to several countries, including Indonesia, to adopt dihydroarteminsin-piperaquine instead. However, the molecular drivers of CQR remain unclear. Using a genome-wide approach, we perform a genomic analysis of 1534 P. vivax isolates across 29 endemic countries, detailing population structure, patterns of relatedness, selection, and resistance profiling, providing insights into potential drivers of CQR. Selective sweeps in a locus proximal to pvmdr1, a putative marker for CQR, along with transcriptional regulation genes, distinguish isolates from Indonesia from those in regions where chloroquine remains highly effective. In 106 isolates from Indonesian Papua, the epicentre of CQR, we observe an increasing prevalence of novel SNPs in the candidate resistance gene pvmrp1 since the introduction of dihydroartemisinin-piperaquine. Overall, we provide novel markers for resistance surveillance, supported by evidence of regions under recent directional selection and temporal analysis in this continually evolving parasite.