Effects of Multispecies Probiotic Supplementation on Serum Bone Turnover Markers in Postmenopausal Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Trial

dc.contributor.authorVanitchanont M.
dc.contributor.authorVallibhakara S.A.O.
dc.contributor.authorSophonsritsuk A.
dc.contributor.authorVallibhakara O.
dc.contributor.correspondenceVanitchanont M.
dc.contributor.otherMahidol University
dc.date.accessioned2024-02-19T18:08:12Z
dc.date.available2024-02-19T18:08:12Z
dc.date.issued2024-02-01
dc.description.abstractProbiotics have been found to have beneficial effects on bone metabolism. In this randomized, double-blind, placebo-controlled trial, the effects of multispecies probiotic supplementation on bone turnover markers were evaluated after 12 weeks. Forty postmenopausal women with osteopenia were included and randomly divided into two groups. The intervention group received multispecies probiotics, while the control group received identical placebo sachets daily. The baseline characteristics of both groups were similar. Still, the median serum bone resorption marker C-terminal telopeptide of type I collagen (CTX) was slightly higher in the multispecies probiotic group than in the placebo group (0.35 (0.12, 0.53) vs. 0.16 (0.06, 0.75); p-value = 0.004). After 12 weeks, the mean difference in serum CTX at baseline versus 12 weeks was significantly different between the multispecies probiotic and placebo groups (−0.06 (−0.29, 0.05) vs. 0.04 (−0.45, 0.67); p-value < 0.001). The multispecies probiotic group showed a significant decrease in serum CTX at 12 weeks compared with baseline (p-value 0.026). However, the placebo group showed no significant change in serum CTX (p-value 0.18). In conclusion, multispecies probiotics may have a preventive effect on bone through their antiresorptive effect in osteopenic postmenopausal women.
dc.identifier.citationNutrients Vol.16 No.3 (2024)
dc.identifier.doi10.3390/nu16030461
dc.identifier.eissn20726643
dc.identifier.pmid38337745
dc.identifier.scopus2-s2.0-85184678635
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/97260
dc.rights.holderSCOPUS
dc.subjectNursing
dc.subjectAgricultural and Biological Sciences
dc.titleEffects of Multispecies Probiotic Supplementation on Serum Bone Turnover Markers in Postmenopausal Women with Osteopenia: A Randomized, Double-Blind, Placebo-Controlled Trial
dc.typeArticle
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85184678635&origin=inward
oaire.citation.issue3
oaire.citation.titleNutrients
oaire.citation.volume16
oairecerif.author.affiliationRamathibodi Hospital

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