Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study
Issued Date
2022-10-01
Resource Type
eISSN
23288957
Scopus ID
2-s2.0-85145089484
Journal Title
Open Forum Infectious Diseases
Volume
9
Issue
10
Rights Holder(s)
SCOPUS
Bibliographic Citation
Open Forum Infectious Diseases Vol.9 No.10 (2022)
Suggested Citation
Chandna A., Mahajan R., Gautam P., Mwandigha L., Kumar P., Varghese G.M., Koshiaris C., Lubell Y., Burza S. Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study. Open Forum Infectious Diseases Vol.9 No.10 (2022). doi:10.1093/ofid/ofac526 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85458
Title
Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study
Author's Affiliation
Angkor Hospital for Children
Mahidol Oxford Tropical Medicine Research Unit
All India Institute of Medical Sciences, Patna
London School of Hygiene & Tropical Medicine
Nuffield Department of Medicine
Medecins Sans Frontieres
University of Oxford Medical Sciences Division
Christian Medical College, Vellore
Mahidol Oxford Tropical Medicine Research Unit
All India Institute of Medical Sciences, Patna
London School of Hygiene & Tropical Medicine
Nuffield Department of Medicine
Medecins Sans Frontieres
University of Oxford Medical Sciences Division
Christian Medical College, Vellore
Other Contributor(s)
Abstract
Efficient resource allocation is essential for effective pandemic response. We measured host biomarkers in 420 patients presenting with moderate coronavirus disease 2019 and found that different biomarkers predict distinct clinical outcomes. Interleukin (IL)-1ra, IL-6, IL-10, and IL-8 exhibit dose-response relationships with subsequent disease progression and could potentially be useful for multiple use-cases.