Association of Preinjury Beta-Blocker Exposure With Brain Injury Biomarkers Following Traumatic Brain Injury
Issued Date
2026-04-01
Resource Type
eISSN
15371921
Scopus ID
2-s2.0-105031953496
Pubmed ID
41024341
Journal Title
Journal of Neurosurgical Anesthesiology
Volume
38
Issue
2
Start Page
155
End Page
160
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Neurosurgical Anesthesiology Vol.38 No.2 (2026) , 155-160
Suggested Citation
Wongsripuemtet P., Ohnuma T., Temkin N., Barber J., Komisarow J., Manley G.T., Hatfield J., Treggiari M.M., Colton K., Sasannejad C., Chaikittisilpa N., Grandhi R., Laskowitz D.T., Mathew J.P., Hernandez A., James M.L., Raghunathan K., Miller J.B., Vavilala M.S., Krishnamoorthy V. Association of Preinjury Beta-Blocker Exposure With Brain Injury Biomarkers Following Traumatic Brain Injury. Journal of Neurosurgical Anesthesiology Vol.38 No.2 (2026) , 155-160. 160. doi:10.1097/ANA.0000000000001063 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/115688
Title
Association of Preinjury Beta-Blocker Exposure With Brain Injury Biomarkers Following Traumatic Brain Injury
Author's Affiliation
University of California, San Francisco
University of Washington School of Medicine
University of Utah School of Medicine
Duke University School of Medicine
Siriraj Hospital
Henry Ford Health System
Departments of Neurosurgery
Critical Care and Perioperative Population Health Research (CAPER) Program
Departments of Biostatistics
University of Washington School of Medicine
University of Utah School of Medicine
Duke University School of Medicine
Siriraj Hospital
Henry Ford Health System
Departments of Neurosurgery
Critical Care and Perioperative Population Health Research (CAPER) Program
Departments of Biostatistics
Corresponding Author(s)
Other Contributor(s)
Abstract
OBJECTIVE: Beta-blockers have been studied for their impact on traumatic brain injury (TBI). We aimed to examine the association of preinjury beta-blocker exposure with early brain injury biomarker levels and outcomes following TBI. METHODS: We retrospectively studied adults (≥40 y) participating in the Transforming Clinical Research and Knowledge in TBI (TRACK-TBI) study. The exposure was preinjury beta-blocker utilization. Primary outcome was blood-based brain injury biomarker levels on day 1 following injury. Secondary outcomes included biomarkers on days 3 and 5, hospital mortality, and the 6-month Glasgow Outcome Scale-Extended. Inverse probability-weighted models assessed the association between preinjury beta-blocker exposure, biomarker levels, and outcomes, stratified by TBI severity. RESULTS: A total of 1185 patients were included, with 101 on preinjury beta-blockers (BB+): 21 in the moderate/severe group and 80 in the mild TBI group. BB+patients were older than BB- in both mild (67 vs. 57 y, P <0.001) and moderate/severe TBI (64 vs. 56 y, P =0.003). Hypertension was more common in BB+patients (78% mild, 67% moderate/severe, P <0.001). Preinjury beta-blocker use was not associated with day 1 biomarker levels. The 6-month GOSE scores in the BB+ moderate/severe TBI were lower, but the effect was marginal (B= -1.20, 95% CI: -2.39 to -0.01, P =0.049). CONCLUSION: Our study did not find a clear association between preinjury beta-blocker exposure and day 1 blood-based brain injury biomarkers or clinical outcomes. These findings warrant confirmation in future studies with larger cohorts.