CRVO associated with COVID-19 and MTHFR mutation in a 15-year-old male
Issued Date
2022-06-01
Resource Type
ISSN
24519936
Scopus ID
2-s2.0-85129540888
Journal Title
American Journal of Ophthalmology Case Reports
Volume
26
Rights Holder(s)
SCOPUS
Bibliographic Citation
American Journal of Ophthalmology Case Reports Vol.26 (2022)
Suggested Citation
Staropoli P.C., Payson A., Negron C.I., Prakhunhungsit S., Laufer P., Berrocal A.M. CRVO associated with COVID-19 and MTHFR mutation in a 15-year-old male. American Journal of Ophthalmology Case Reports Vol.26 (2022). doi:10.1016/j.ajoc.2022.101522 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85834
Title
CRVO associated with COVID-19 and MTHFR mutation in a 15-year-old male
Author's Affiliation
Other Contributor(s)
Abstract
Purpose: To report a case of a central retinal vein occlusion (CRVO) associated with COVID-19 in a patient predisposed to clotting due to a genetic mutation in methylenetetrahydrofolate reductase (MTHFR). Observations: A 15-year-old male presented with 1 day of painless blurry vision in the left eye. Exam disclosed trace anterior chamber cell, anterior vitreous cell, optic nerve head edema, temporally displaced macular star, dilated tortuous veins, and diffuse intraretinal hemorrhages. Exam and FA was consistent with CRVO, however the macular star and OCT were suggestive of a neuroretinitis. The patient then presented to a children's hospital for further evaluation. A routine screen for COVID-19 via nasopharyngeal swab was positive with a high viral load. He also had a known history of an MTHFR mutation. Extensive laboratory and neuroradiologic evaluation excluded other infectious, inflammatory, and coagulopathic etiologies. Conclusions and Importance: This is a case of CRVO associated with COVID-19 infection and an underlying systemic hypercoagulable mutation, with an initial presentation that mimicked neuroretinitis. This case provides valuable diagnostic learning points and expands our knowledge of possible ocular complications of COVID-19.