Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance

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dc.contributor.authorMunk P.
dc.contributor.authorBrinch C.
dc.contributor.authorMøller F.D.
dc.contributor.authorPetersen T.N.
dc.contributor.authorHendriksen R.S.
dc.contributor.authorSeyfarth A.M.
dc.contributor.authorKjeldgaard J.S.
dc.contributor.authorSvendsen C.A.
dc.contributor.authorvan Bunnik B.
dc.contributor.authorBerglund F.
dc.contributor.authorBego A.
dc.contributor.authorPower P.
dc.contributor.authorRees C.
dc.contributor.authorLambrinidis D.
dc.contributor.authorNeilson E.H.J.
dc.contributor.authorGibb K.
dc.contributor.authorCoventry K.
dc.contributor.authorCollignon P.
dc.contributor.authorCassar S.
dc.contributor.authorAllerberger F.
dc.contributor.authorBegum A.
dc.contributor.authorHossain Z.Z.
dc.contributor.authorWorrell C.
dc.contributor.authorVandenberg O.
dc.contributor.authorPieters I.
dc.contributor.authorVictorien D.T.
dc.contributor.authorGutierrez A.D.S.
dc.contributor.authorSoria F.
dc.contributor.authorGrujić V.R.
dc.contributor.authorMazalica N.
dc.contributor.authorRahube T.O.
dc.contributor.authorTagliati C.A.
dc.contributor.authorRodrigues D.
dc.contributor.authorOliveira G.
dc.contributor.authorde Souza L.C.R.
dc.contributor.authorIvanov I.
dc.contributor.authorJuste B.I.
dc.contributor.authorOumar T.
dc.contributor.authorSopheak T.
dc.contributor.authorVuthy Y.
dc.contributor.authorNgandijo A.
dc.contributor.authorNzouankeu A.
dc.contributor.authorOlivier Z.A.A.J.
dc.contributor.authorYost C.K.
dc.contributor.authorKumar P.
dc.contributor.authorBrar S.K.
dc.contributor.authorTabo D.A.
dc.contributor.authorAdell A.D.
dc.contributor.authorParedes-Osses E.
dc.contributor.authorMartinez M.C.
dc.contributor.authorSara C.O.
dc.contributor.authorKe C.
dc.contributor.authorZheng H.
dc.contributor.authorBaisheng L.
dc.contributor.authorLau L.T.
dc.contributor.authorChung T.
dc.contributor.authorJiao X.
dc.contributor.authorYu Y.
dc.contributor.authorJiaYong Z.
dc.contributor.authorMorales J.F.B.
dc.contributor.authorValencia M.F.
dc.contributor.authorDonado-Godoy P.
dc.contributor.authorCoulibaly K.J.
dc.contributor.authorHrenovic J.
dc.contributor.authorJergović M.
dc.contributor.authorKarpíšková R.
dc.contributor.authorDeogratias Z.N.
dc.contributor.authorElsborg B.
dc.contributor.authorHansen L.T.
dc.contributor.authorJensen P.E.
dc.contributor.authorAbouelnaga M.
dc.contributor.authorSalem M.F.
dc.contributor.authorKoolmeister M.
dc.contributor.authorLegesse M.
dc.contributor.authorEguale T.
dc.contributor.authorHeikinheimo A.
dc.contributor.authorLe Guyader S.
dc.contributor.authorSchaeffer J.
dc.contributor.authorVillacis J.E.
dc.contributor.authorSanneh B.
dc.contributor.authorMalania L.
dc.contributor.authorNitsche A.
dc.contributor.authorBrinkmann A.
dc.contributor.authorSchubert S.
dc.contributor.authorHesse S.
dc.contributor.authorBerendonk T.U.
dc.contributor.authorSaba C.K.S.
dc.contributor.authorMohammed J.
dc.contributor.authorFeglo P.K.
dc.contributor.authorBanu R.A.
dc.contributor.authorKotzamanidis C.
dc.contributor.authorLytras E.
dc.contributor.authorLickes S.A.
dc.contributor.authorKocsis B.
dc.contributor.authorSolymosi N.
dc.contributor.authorThorsteinsdottir T.R.
dc.contributor.authorHatha A.M.
dc.contributor.authorBallal M.
dc.contributor.authorBangera S.R.
dc.contributor.authorFani F.
dc.contributor.otherMahidol University
dc.date.accessioned2023-06-18T18:15:55Z
dc.date.available2023-06-18T18:15:55Z
dc.date.issued2022-12-01
dc.description.abstractAntimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.
dc.identifier.citationNature Communications Vol.13 No.1 (2022)
dc.identifier.doi10.1038/s41467-022-34312-7
dc.identifier.eissn20411723
dc.identifier.pmid36456547
dc.identifier.scopus2-s2.0-85143185703
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/86905
dc.rights.holderSCOPUS
dc.subjectPhysics and Astronomy
dc.titleGenomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
dc.typeArticle
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85143185703&origin=inward
oaire.citation.issue1
oaire.citation.titleNature Communications
oaire.citation.volume13
oairecerif.author.affiliationInstituto Tecnológico Vale
oairecerif.author.affiliationUniversity of Sadat City
oairecerif.author.affiliationBotswana International University of Science and Technology
oairecerif.author.affiliationUniversity of Banja Luka
oairecerif.author.affiliationMelbourne Water Corporation
oairecerif.author.affiliationGuangdong Center for Disease Control and Prevention
oairecerif.author.affiliationUniversite de N'Djamena
oairecerif.author.affiliationUniversidad de San Carlos de Guatemala
oairecerif.author.affiliationInstitute of Public Health Albania
oairecerif.author.affiliationUniversity of Ouagadougou
oairecerif.author.affiliationInstitut Pasteur du Cambodge
oairecerif.author.affiliationInstitut Pasteur de Cote-d'Ivoire
oairecerif.author.affiliationUniversity for Development Studies Ghana
oairecerif.author.affiliationKwame Nkrumah University of Science and Technology
oairecerif.author.affiliationCSIR - Water Research Institute Ghana
oairecerif.author.affiliationAddis Ababa University
oairecerif.author.affiliationHaskoli Islands
oairecerif.author.affiliationInstitut National de la Recherche Scientifique
oairecerif.author.affiliationCentre Pasteur du Cameroun
oairecerif.author.affiliationAquafin, Belgium
oairecerif.author.affiliationNanjing University of Information Science & Technology
oairecerif.author.affiliationCochin University of Science and Technology
oairecerif.author.affiliationChinese Center for Disease Control and Prevention
oairecerif.author.affiliationKøbenhavns Universitet
oairecerif.author.affiliationUniversity of Regina
oairecerif.author.affiliationUniversidade Federal de Minas Gerais
oairecerif.author.affiliationVeterinary Research Institute, Brno
oairecerif.author.affiliationHellenic Agricultural Organization-DIMITRAADA
oairecerif.author.affiliationNational Center of Infectious and Parasitic Diseases Bulgaria
oairecerif.author.affiliationThe University of Edinburgh
oairecerif.author.affiliationÁltalános Orvostudományi Kar
oairecerif.author.affiliationFundacao Oswaldo Cruz
oairecerif.author.affiliationShiraz University of Medical Sciences
oairecerif.author.affiliationSuez Canal University
oairecerif.author.affiliationIFREMER Institut Francais de Recherche pour l'Exploitation de la Mer
oairecerif.author.affiliationTechnische Universität Dresden
oairecerif.author.affiliationUniversity of Ghana
oairecerif.author.affiliationCanberra Hospital
oairecerif.author.affiliationGöteborgs Universitet
oairecerif.author.affiliationRobert Koch Institut
oairecerif.author.affiliationKasturba Medical College, Manipal
oairecerif.author.affiliationUniversity of Dhaka
oairecerif.author.affiliationTechnical University of Denmark
oairecerif.author.affiliationShantou University Medical College
oairecerif.author.affiliationInstituto de Salud Publica de Chile
oairecerif.author.affiliationUniversidad Católica del Maule
oairecerif.author.affiliationHong Kong Polytechnic University
oairecerif.author.affiliationUniversity of Zagreb
oairecerif.author.affiliationUniversity of Zagreb School of Medicine
oairecerif.author.affiliationUniversity of Veterinary Medicine Budapest
oairecerif.author.affiliationCharles Darwin University
oairecerif.author.affiliationAustrian Agency for Health and Food Safety
oairecerif.author.affiliationHelsingin Yliopisto
oairecerif.author.affiliationUniversidad Andrés Bello
oairecerif.author.affiliationUniversidad de Buenos Aires
oairecerif.author.affiliationCI Tibaitatα
oairecerif.author.affiliationApollo Diagnostics
oairecerif.author.affiliationGalαpagos
oairecerif.author.affiliationUniversidad Catσlica Boliviana San Pablo
oairecerif.author.affiliationPolytechnic School of Abomey-Calavi (EPAC)
oairecerif.author.affiliationLaboratoire Hospitalier Universitaire de Bruxelles (LHUB-ULB)
oairecerif.author.affiliationMinistry of Health and Social Welfare
oairecerif.author.affiliationNational Center for Disease Control and Public Health
oairecerif.author.affiliationALS Water
oairecerif.author.affiliationBIOFOS A/S
oairecerif.author.affiliationCentre de Recherche en Sciences Naturelles (CRSN)
oairecerif.author.affiliationMinistry of Health
oairecerif.author.affiliationPublic Health Institute of Republic of Srpska
oairecerif.author.affiliationBridgetown
oairecerif.author.affiliationAthens Water Supply and Sewerage Company (EYDAP SA)

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