Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder
1
Issued Date
2023-12-01
Resource Type
eISSN
21947511
Scopus ID
2-s2.0-85162906391
Journal Title
International Journal of Bipolar Disorders
Volume
11
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Bipolar Disorders Vol.11 No.1 (2023)
Suggested Citation
Bauer M. Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder. International Journal of Bipolar Disorders Vol.11 No.1 (2023). doi:10.1186/s40345-023-00303-w Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/87785
Title
Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder
Author(s)
Author's Affiliation
Faculty of Health Sciences
Universitätsklinikum Carl Gustav Carus Dresden
Université Paris Cité
Centre for Youth Mental Health
Melbourne Medical School
Hospital Universitario Araba
Azienda Ospedaliero Universitaria di Cagliari
Université Paris-Saclay
Oslo Universitetssykehus
National Institute for Health and Welfare
MSU College of Human Medicine
Datta Meghe Institute of Higher Education & Research (Deemed to be University)
Bahar Dar University
Klinicki Centar Srbije
Poznan University of Medical Sciences
Tartu Ülikool
School of Medicine
Universidad de Antioquia
Università degli Studi di Cagliari
Michigan State University
University of Ottawa
Başkent Üniversitesi
Universidad del Pais Vasco
Sahlgrenska Akademin
Ben-Gurion University of the Negev
University of Melbourne
Keio University School of Medicine
Université Paris-Est Créteil Val de Marne
Universität zu Köln
Dalhousie University, Faculty of Medicine
IRCCS Ospedale San Raffaele
Universitetssykehuset i Trondheim
Hôpital Bichat-Claude-Bernard AP-HP
Tokyo Metropolitan Matsuzawa Hospital
Aalborg University
Hacettepe Üniversitesi
Syddansk Universitet
Deakin University
University of Toronto
National Institute of Mental Health and Neuro Sciences
Aalborg Universitetshospital
Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze
Copenhagen University Hospital
Selçuk Tip Fakültesi
Northwestern University Feinberg School of Medicine
Norges Teknisk-Naturvitenskapelige Universitet
Karolinska Institutet
Trinity College Dublin
Chosun University
Università Vita-Salute San Raffaele
Singapore Institute of Mental Health
Universitätsklinikum Frankfurt
University of Southern Denmark, Esbjerg
Universidade de São Paulo
Universidade Federal do Rio Grande do Sul
Jane & Terry Semel Institute for Neuroscience & Human Behavior
Medizinische Universität Graz
Veterans General Hospital-Taichung Taiwan
Universitair Medisch Centrum Groningen
Mayo Clinic
Helsingin Yliopisto
University of Otago, Christchurch
Instituto Nacional de Psiquiatría Ramon de la Fuente
University of Glasgow
University of Massachusetts Chan Medical School
Westfälische Wilhelms-Universität Münster
Khanty-Mansiysk Clinical Psychoneurological Hospital
The Psychology Clinic of East Anglia
ChronoRecord Association
BIPOLAR Zentrum Wiener Neustadt
Dr. Jose Horwitz Psychiatric Institute
Mataram University
Institute of Psychiatry and Neurosciences
Private Practice
Psychiatric Center Copenhagen
SHG-Klinik
Butabika Hospital
Pine Rest Christian Mental Health Services
Universitätsklinikum Carl Gustav Carus Dresden
Université Paris Cité
Centre for Youth Mental Health
Melbourne Medical School
Hospital Universitario Araba
Azienda Ospedaliero Universitaria di Cagliari
Université Paris-Saclay
Oslo Universitetssykehus
National Institute for Health and Welfare
MSU College of Human Medicine
Datta Meghe Institute of Higher Education & Research (Deemed to be University)
Bahar Dar University
Klinicki Centar Srbije
Poznan University of Medical Sciences
Tartu Ülikool
School of Medicine
Universidad de Antioquia
Università degli Studi di Cagliari
Michigan State University
University of Ottawa
Başkent Üniversitesi
Universidad del Pais Vasco
Sahlgrenska Akademin
Ben-Gurion University of the Negev
University of Melbourne
Keio University School of Medicine
Université Paris-Est Créteil Val de Marne
Universität zu Köln
Dalhousie University, Faculty of Medicine
IRCCS Ospedale San Raffaele
Universitetssykehuset i Trondheim
Hôpital Bichat-Claude-Bernard AP-HP
Tokyo Metropolitan Matsuzawa Hospital
Aalborg University
Hacettepe Üniversitesi
Syddansk Universitet
Deakin University
University of Toronto
National Institute of Mental Health and Neuro Sciences
Aalborg Universitetshospital
Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze
Copenhagen University Hospital
Selçuk Tip Fakültesi
Northwestern University Feinberg School of Medicine
Norges Teknisk-Naturvitenskapelige Universitet
Karolinska Institutet
Trinity College Dublin
Chosun University
Università Vita-Salute San Raffaele
Singapore Institute of Mental Health
Universitätsklinikum Frankfurt
University of Southern Denmark, Esbjerg
Universidade de São Paulo
Universidade Federal do Rio Grande do Sul
Jane & Terry Semel Institute for Neuroscience & Human Behavior
Medizinische Universität Graz
Veterans General Hospital-Taichung Taiwan
Universitair Medisch Centrum Groningen
Mayo Clinic
Helsingin Yliopisto
University of Otago, Christchurch
Instituto Nacional de Psiquiatría Ramon de la Fuente
University of Glasgow
University of Massachusetts Chan Medical School
Westfälische Wilhelms-Universität Münster
Khanty-Mansiysk Clinical Psychoneurological Hospital
The Psychology Clinic of East Anglia
ChronoRecord Association
BIPOLAR Zentrum Wiener Neustadt
Dr. Jose Horwitz Psychiatric Institute
Mataram University
Institute of Psychiatry and Neurosciences
Private Practice
Psychiatric Center Copenhagen
SHG-Klinik
Butabika Hospital
Pine Rest Christian Mental Health Services
Other Contributor(s)
Abstract
Background: Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample. Methods: Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001. Results: The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger. Conclusion: UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.