SYNTHESIS OF ACETAMIDOSULFONAMIDE DERIVATIVES WITH ANTIOXIDATIVE AND QSAR STUDIES
1
Issued Date
2022-01-03
Resource Type
eISSN
16112156
Scopus ID
2-s2.0-85127639321
Journal Title
EXCLI Journal
Volume
21
Start Page
360
End Page
379
Rights Holder(s)
SCOPUS
Bibliographic Citation
EXCLI Journal Vol.21 (2022) , 360-379
Suggested Citation
Worachartcheewan A., Pisutjaroenpong S., Pingaew R., Prachayasittikul S., Siriwong S., Ruchirawat S., Prachayasittikul V. SYNTHESIS OF ACETAMIDOSULFONAMIDE DERIVATIVES WITH ANTIOXIDATIVE AND QSAR STUDIES. EXCLI Journal Vol.21 (2022) , 360-379. 379. doi:10.17179/excli2021-4590 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/83862
Title
SYNTHESIS OF ACETAMIDOSULFONAMIDE DERIVATIVES WITH ANTIOXIDATIVE AND QSAR STUDIES
Other Contributor(s)
Abstract
A series of sixteen acetamidosulfonamide derivatives (1-16) have been synthesized and investigated for their antioxidant (radical scavenging and superoxide dismutase (SOD)) and antimicrobial activities. Most compounds exhibited antioxidant activities in which compound 15 displayed the most potent radical scavenging and SOD activities. Quantitative structure-activity relationship (QSAR) has been studied using multiple linear regression. 2 The constructed QSAR models displayed high correlation coefficient (QLOO- = 0.9708 and 0.8753 for RSA CV and SOD activities, respectively), but low root mean square error (RMSELOO-CV = 0.5105 and 1.3571 for RSA and SOD activities, respectively). The structure-activity relationship showed that an ethylene group connected to pyridine ring provided significant antioxidant activities. The QSAR models give insight into the rational designed of eighty new sulfonamides with various electron donating and withdrawing groups. The top five new designed sulfonamides with nitro group are potential antioxidants to be further developed for medicinal applications.