Relationship between Helicobacter Pylori Infection and the Risk of Esophageal Cancer in Thailand
7
Issued Date
2023-01-01
Resource Type
ISSN
15137368
eISSN
2476762X
Scopus ID
2-s2.0-85150986469
Pubmed ID
36974563
Journal Title
Asian Pacific Journal of Cancer Prevention
Volume
24
Issue
3
Start Page
1073
End Page
1080
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Cancer Prevention Vol.24 No.3 (2023) , 1073-1080
Suggested Citation
Poosari A., Nutravong T., Namwat W., Sa-ngiamwibool P., Ungareewittaya P., Boonyanugomol W. Relationship between Helicobacter Pylori Infection and the Risk of Esophageal Cancer in Thailand. Asian Pacific Journal of Cancer Prevention Vol.24 No.3 (2023) , 1073-1080. 1080. doi:10.31557/APJCP.2023.24.3.1073 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/82321
Title
Relationship between Helicobacter Pylori Infection and the Risk of Esophageal Cancer in Thailand
Author's Affiliation
Other Contributor(s)
Abstract
Objective: Esophageal cancer (EC) is a multifactorial disease and a leading cause of mortality. Epidemiological and molecular studies have provided evidence that Helicobacter pylori (H. pylori) infection is an important cause of gastric carcinogenesis and thus, may be related to EC. However, esophagus H. pylori infection in Thai patients with newly diagnosed EC has not been reported. Moreover, the evidence of the association with H. pylori to EC is controversial. This study investigated the possible association between H. pylori infection with a virulence gene and EC in Thailand. Methods: A case-control study was conducted that involved 105 newly diagnosed EC patients and 108 healthy controls. The prevalence of H. pylori infection detected in formalin-fixed, paraffin-embedded EC tissue in esophageal biopsy specimens from the subjects was measured using real-time PCR. All the data were collected in face to face interviews using a structured questionnaire. Multivariable unconditional logistic regression was used to calculate and analyses the odds ratios (ORs) of the data. Results: A significant association was found between H. pylori infection and EC (p < 0.001, 95% CI:3.11–10.48). H. pylori-positive subjects had a 2.76 times higher risk of developing ESCC. Moreover, the H. pylori-positive subjects who were CagA-positive had slightly higher ORs and statistically significant risk factors. Conclusions: H. pylori infection was found to be associated with a risk of EC in Thailand, and among the H. pyloripositive subjects who were CagA-positive had a higher risk factor of ESCC but not of EAC.