Metal-Free Aminomethylation of Pyrazolones: Direct Access to 4-Aminomethylated Pyrazolones
Issued Date
2022-10-01
Resource Type
ISSN
21935807
Scopus ID
2-s2.0-85138306756
Journal Title
Asian Journal of Organic Chemistry
Volume
11
Issue
10
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Journal of Organic Chemistry Vol.11 No.10 (2022)
Suggested Citation
Phakdeeyothin K., Viriyanukul T., Udomsasporn K., Phomphrai K., Yotphan S. Metal-Free Aminomethylation of Pyrazolones: Direct Access to 4-Aminomethylated Pyrazolones. Asian Journal of Organic Chemistry Vol.11 No.10 (2022). doi:10.1002/ajoc.202200467 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/84155
Title
Metal-Free Aminomethylation of Pyrazolones: Direct Access to 4-Aminomethylated Pyrazolones
Author's Affiliation
Other Contributor(s)
Abstract
A metal-free aminomethylation of pyrazolones is accomplished with cyclic amines such as morpholine and piperazine analogues in the presence of (diacetoxyiodo)benzene at ambient temperature. Various sensitive functional groups can be compatible under the reaction conditions. Preliminary mechanistic investigation reveals that morpholine or piperazine analogues are likely to be the source of methylene group. This method provides a straightforward route for the preparation of 4-aminomethylated pyrazolone derivatives under mild conditions.