Research Progress of Indole Alkaloids: Targeting MAP Kinase Signaling Pathways in Cancer Treatment
Issued Date
2023-11-01
Resource Type
eISSN
20726694
Scopus ID
2-s2.0-85178104672
Journal Title
Cancers
Volume
15
Issue
22
Rights Holder(s)
SCOPUS
Bibliographic Citation
Cancers Vol.15 No.22 (2023)
Suggested Citation
Al Amin M., Emran T.B., Khan J., Zehravi M., Sharma I., Patil A., Gupta J.K., Jeslin D., Krishnan K., Das R., Nainu F., Ahmad I., Wilairatana P. Research Progress of Indole Alkaloids: Targeting MAP Kinase Signaling Pathways in Cancer Treatment. Cancers Vol.15 No.22 (2023). doi:10.3390/cancers15225311 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/91340
Title
Research Progress of Indole Alkaloids: Targeting MAP Kinase Signaling Pathways in Cancer Treatment
Author's Affiliation
Buraydah Private Colleges
KLE College of Pharmacy, Bengaluru
Faculty of Tropical Medicine, Mahidol University
GLA University, Mathura
Vels Institute of Science, Technology & Advanced Studies
Sree Balaji Medical College & Hospital
International Islamic University Chittagong
Hasanuddin University
King Khalid University
Daffodil International University
University of Dhaka
The Warren Alpert Medical School
Career Point University
KLE College of Pharmacy, Bengaluru
Faculty of Tropical Medicine, Mahidol University
GLA University, Mathura
Vels Institute of Science, Technology & Advanced Studies
Sree Balaji Medical College & Hospital
International Islamic University Chittagong
Hasanuddin University
King Khalid University
Daffodil International University
University of Dhaka
The Warren Alpert Medical School
Career Point University
Other Contributor(s)
Abstract
Cancer is the leading cause of morbidity and mortality in people throughout the world. There are many signaling pathways associated with cancerous diseases, from which the Mitogen-activated protein kinase (MAPK) pathway performs a significant role in this regard. Apoptosis and proliferation are correlated with MAPK signaling pathways. Plenty of experimental investigations were carried out to assess the role of indole alkaloids in MAPK-mediated cancerous diseases. Previous reports established that indole alkaloids, such as vincristine and evodiamine are useful small molecules in cancer treatment via the MAPK signaling system. Indole alkaloids have the anticancer potential through different pathways. Vincristine and evodiamine are naturally occurring indole alkaloids that have strong anticancer properties. Additionally, much research is ongoing or completed with molecules belonging to this group. The current review aims to evaluate how indole alkaloids affect the MAPK signaling pathway in cancer treatment. Additionally, we focused on the advancement in the role of indole alkaloids, with the intention of modifying the MAPK signaling pathways to investigate potential new anticancer small molecules. Furthermore, clinical trials with indole alkaloids in cancer treatment are also highlighted.