Elevated serum IL-34 is correlated with disease severity in patients with biliary atresia following Kasai portoenterostomy
Issued Date
2024-01-25
Resource Type
ISSN
15675769
eISSN
18781705
Scopus ID
2-s2.0-85180115024
Pubmed ID
38103407
Journal Title
International Immunopharmacology
Volume
127
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Immunopharmacology Vol.127 (2024)
Suggested Citation
Honsawek S., Bovornsethanant N., Woraruthai T., Vejchapipat P., Udomsinprasert W., Poovorawan Y. Elevated serum IL-34 is correlated with disease severity in patients with biliary atresia following Kasai portoenterostomy. International Immunopharmacology Vol.127 (2024). doi:10.1016/j.intimp.2023.111356 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/95950
Title
Elevated serum IL-34 is correlated with disease severity in patients with biliary atresia following Kasai portoenterostomy
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Abstract
Background: Biliary atresia (BA) is a severe congenital disorder with progressive obstructive cholangiopathy in young children. The inflammatory process has been recognized as one of the pathological mechanisms driving bile duct injury. Since interleukin-34 (IL-34) has been reportedly linked to several pathological liver disorders, including inflammation, the current study aimed to analyze circulating IL-34 and the association of circulating IL-34 with hepatic deterioration and clinical outcomes in post-Kasai BA children. Methods: Circulating IL-34 levels were analyzed in 89 post-Kasai BA subjects and 45 healthy individuals using an ELISA. Liver stiffness (hardness) was measured by ultrasound elastography. Results: Circulating IL-34 was substantially higher in BA children than in control individuals, particularly those with unfavorable outcomes including hepatic dysfunction, jaundice, and portal hypertension. In BA group, circulating IL-34 was positively correlated with liver stiffness (r = 0.515, p < 0.001), AST (r = 0.403, p < 0.001), ALT (r = 0.279, p = 0.008), total bilirubin (r = 0.224, p = 0.03), ALP (r = 0.255, p = 0.016), and serum IL-6 (r = 0.590, p < 0.001) but inversely correlated with albumin (r = -0.417, p < 0.001). Kaplan-Meier survival analysis showed that higher circulating IL-34 levels were significantly associated with reduced survival rates in BA subjects (p = 0.002). Conclusion: Higher circulating IL-34 values were directly associated with hepatic impairment and the BA severity, implicating that serum IL-34 could be applied as a noninvasive marker for the monitoring of the severity in BA subjects following Kasai portoenterostomy and therapeutic efficacy.