Effect of vitamin E on cholesterol metabolism in rabbits
2
Issued Date
1988
Copyright Date
1988
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
viii, 94 leaves : ill. 30 cm
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Biochemistry))--Mahidol University, 1988
Suggested Citation
Chaveewon Porntadavity Effect of vitamin E on cholesterol metabolism in rabbits. Thesis (M.Sc. (Biochemistry))--Mahidol University, 1988. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/103394
Title
Effect of vitamin E on cholesterol metabolism in rabbits
Alternative Title(s)
ผลของวิตามินอีต่อเมตาบอลิสมของคลอเลสเตอรอลในกระต่าย
Author(s)
Advisor(s)
Abstract
The purpose of this study was to find out the mechanism for the hypocholesterolemic effect of vitamin E in rabbits. The animals were fed a purified basal diet deficient in vitamin E and were supplemented with varying amounts of DL-?-tocopherol acetate, namely 21, 210 and 2,100 mg/week for 10 weeks. There was a significant increase in plasma cholesterol in rabbits supplemented with only corn oil after 6 weeks. Increased vitamin E supplementation reduced plasma cholesterol level. In liver, cholesterol and phospholipid contents were not significantly different in rabbits supplemented with varying amount of vitamin E. The activity of HMG-CoA reductase was also not affected by high level of vitamin E. Liver membranes prepared from rabbits supplemented with these amounts of vitamin E showed no differences in total binding with (125)I-LDL, indicating that the number of LDL receptors did not increase as the amount of vitamin E supplementation increased. The results of in vitro binding were consistent with the finding that the clearance rates of (125)I-LDL in rabbits supplemented with varying amounts of vitamin E were not significantly different. These results suggested that decreased plasma cholesterol in vitamin E supplemented rabbits did not involve cholesterols metabolism in liver. The decreased plasma cholesterol in vitamin E supplemented rabbits may be due to a decrease in absorption of cholesterol.
Description
Biochemistry (Mahidol University 1988)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Biochemistry
Degree Grantor(s)
Mahidol University