Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations
Issued Date
2022-03-01
Resource Type
eISSN
19994923
Scopus ID
2-s2.0-85126449704
Journal Title
Pharmaceutics
Volume
14
Issue
3
Rights Holder(s)
SCOPUS
Bibliographic Citation
Pharmaceutics Vol.14 No.3 (2022)
Suggested Citation
Raina N., Pahwa R., Bhattacharya J., Paul A.K., Nissapatorn V., Pereira M.d.L., Oliveira S.M.R., Dolma K.G., Rahmatullah M., Wilairatana P., Gupta M. Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations. Pharmaceutics Vol.14 No.3 (2022). doi:10.3390/pharmaceutics14030574 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86877
Title
Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations
Author's Affiliation
Faculty of Tropical Medicine, Mahidol University
Sikkim Manipal Institute of Medical Sciences
Hunter Medical Research Institute, Australia
Kurukshetra University
Jawaharlal Nehru University
Walailak University
Universidade de Aveiro
University of Tasmania
CICECO – Instituto de Materiais de Aveiro
Delhi Pharmaceutical Sciences and Research University
University of Development Alternative
Sikkim Manipal Institute of Medical Sciences
Hunter Medical Research Institute, Australia
Kurukshetra University
Jawaharlal Nehru University
Walailak University
Universidade de Aveiro
University of Tasmania
CICECO – Instituto de Materiais de Aveiro
Delhi Pharmaceutical Sciences and Research University
University of Development Alternative
Other Contributor(s)
Abstract
Hydrogels are a promising and attractive option as polymeric gel networks, which have immensely fascinated researchers across the globe because of their outstanding characteristics such as elevated swellability, the permeability of oxygen at a high rate, good biocompatibility, easy loading, and drug release. Hydrogels have been extensively used for several purposes in the biomedical sector using versatile polymers of synthetic and natural origin. This review focuses on functional polymeric materials for the fabrication of hydrogels, evaluation of different parameters of biocompatibility and stability, and their application as carriers for drugs delivery, tissue engineering and other therapeutic purposes. The outcome of various studies on the use of hydrogels in different segments and how they have been appropriately altered in numerous ways to attain the desired targeted delivery of therapeutic agents is summarized. Patents and clinical trials conducted on hydrogel-based products, along with scale-up translation, are also mentioned in detail. Finally, the potential of the hydrogel in the biomedical sector is discussed, along with its further possibilities for improvement for the development of sophisticated smart hydrogels with pivotal biomedical functions.