Translation and validation of the Thai version of health-related quality of life measure for children with epilepsy (CHEQOL-25)

Abstract

Purpose: This study aimed to translate and validate the Health-Related Quality of Life Measure for Children with Epilepsy (CHEQOL-25) into Thai version (TH-CHEQOL-25), and to evaluate factors affecting quality of life (QOL). Methods: After approval by the original developer, cross cultural adaptation process of CHEQOL-25 was performed including forward translation by two translators, reconciliation, backward translation, and final approval by the original creator. TH-CHEQOL-25 was completed by 161 children with epilepsy aged 6–15 years and their parents twice in 10–14 days to assess its reliability and validity. Content validity was measured by an index of item-objective congruence (IOC) and a content validity index (CVI). The face validity and construct validity were assessed. Results: Internal consistency reliability, evaluated by Cronbach's α coefficient showed the acceptable reliability in three subscales of child self-report and four subscales of parent-proxy response scale. Both versions had good test–retest reliability as ICC for all items ranged between 0.68–0.85. The correlations between child-report and parent-proxy were acceptable. Higher number of anticonvulsants was significantly negatively correlated with poor QOL. Conclusions: TH-CHEQOL-25 is a reliable and valid tool to assess health-related QOL in Thai children with epilepsy. The parent-proxy version can be used if children cannot report it themselves.