An insight into the anticancer potentials of lignan arctiin: A comprehensive review of molecular mechanisms
Issued Date
2024-06-30
Resource Type
ISSN
24058440
Scopus ID
2-s2.0-85196001955
Journal Title
Heliyon
Volume
10
Issue
12
Rights Holder(s)
SCOPUS
Bibliographic Citation
Heliyon Vol.10 No.12 (2024)
Suggested Citation
Chowdhury R., Bhuia M.S., Wilairatana P., Afroz M., Hasan R., Ferdous J., Rakib A.I., Sheikh S., Mubarak M.S., Islam M.T. An insight into the anticancer potentials of lignan arctiin: A comprehensive review of molecular mechanisms. Heliyon Vol.10 No.12 (2024). doi:10.1016/j.heliyon.2024.e32899 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/98917
Title
An insight into the anticancer potentials of lignan arctiin: A comprehensive review of molecular mechanisms
Corresponding Author(s)
Other Contributor(s)
Abstract
Natural products are being developed as possible treatment options due to the rising prevalence of cancer and the harmful side effects of synthetic medications. Arctiin is a naturally occurring lignan found in numerous plants and exhibits different pharmacological activities, along with cancer. To elucidate the anticancer properties and underlying mechanisms of action, a comprehensive search of various electronic databases was conducted using appropriate keywords to identify relevant publications. The findings suggest that arctiin exhibits anticancer properties against tumor formation and various cancers such as cervical, myeloma, prostate, endothelial, gastric, and colon cancers in several preclinical pharmacological investigations. This naturally occurring compound exerts its anticancer effect through different cellular mechanisms, including mitochondrial dysfunction, cell cycle at different phases (G2/M), inhibition of cell proliferation, apoptotic cell death, and cytotoxic effects, as well as inhibition of migration and invasion of various malignant cells. Moreover, the study also revealed that, among the various cellular pathways, arctiin was shown to be more potent in terms of the PI3K/AKT and JAK/STAT signaling pathways. However, pharmacokinetic investigation indicated the compound's poor oral bioavailability. Because of these findings, arctiin might be considered a promising chemotherapeutic drug candidate.