Mechanisms of muscle cells alterations and regeneration decline during aging
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Issued Date
2024-12-01
Resource Type
ISSN
15681637
eISSN
18729649
Scopus ID
2-s2.0-85210039181
Journal Title
Ageing Research Reviews
Volume
102
Rights Holder(s)
SCOPUS
Bibliographic Citation
Ageing Research Reviews Vol.102 (2024)
Suggested Citation
Chinvattanachot G., Rivas D., Duque G. Mechanisms of muscle cells alterations and regeneration decline during aging. Ageing Research Reviews Vol.102 (2024). doi:10.1016/j.arr.2024.102589 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/102236
Title
Mechanisms of muscle cells alterations and regeneration decline during aging
Author(s)
Corresponding Author(s)
Other Contributor(s)
Abstract
Skeletal muscles are essential for locomotion and body metabolism regulation. As muscles age, they lose strength, elasticity, and metabolic capability, leading to ineffective motion and metabolic derangement. Both cellular and extracellular alterations significantly influence muscle aging. Satellite cells (SCs), the primary muscle stem cells responsible for muscle regeneration, become exhausted, resulting in diminished population and functionality during aging. This decline in SC function impairs intercellular interactions as well as extracellular matrix production, further hindering muscle regeneration. Other muscle-resident cells, such as fibro-adipogenic progenitors (FAPs), pericytes, and immune cells, also deteriorate with age, reducing local growth factor activities and responsiveness to stress or injury. Systemic signaling, including hormonal changes, contributes to muscle cellular catabolism and disrupts muscle homeostasis. Collectively, these cellular and environmental components interact, disrupting muscle homeostasis and regeneration in advancing age. Understanding these complex interactions offers insights into potential regenerative strategies to mitigate age-related muscle degeneration.