Intra-serotypic antigenic diversity of dengue virus serotype 3 in Thailand during 2004-2015
Issued Date
2024-01-08
Resource Type
ISSN
09502688
eISSN
14694409
Scopus ID
2-s2.0-85182222842
Pubmed ID
38185822
Journal Title
Epidemiology and Infection
Volume
152
Rights Holder(s)
SCOPUS
Bibliographic Citation
Epidemiology and Infection Vol.152 (2024)
Suggested Citation
Masrinoul P., Sun-Arlee P., Yoksan S., Wanlayaporn D., Juntarapornchai S., Punyahathaikul S., Ketsuwan K., Palabodeewat S., Kongchanagul A., Auewarakul P. Intra-serotypic antigenic diversity of dengue virus serotype 3 in Thailand during 2004-2015. Epidemiology and Infection Vol.152 (2024). doi:10.1017/S0950268823001991 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/95969
Title
Intra-serotypic antigenic diversity of dengue virus serotype 3 in Thailand during 2004-2015
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Corresponding Author(s)
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Abstract
In addition to the well-known differences among the four dengue serotypes, intra-serotypic antigenic diversity has been proposed to play a role in viral evolution and epidemic fluctuation. A replacement of genotype II by genotype III of dengue virus serotype 3 (DENV3) occurred in Thailand during 2007-2014, raising questions about the role of intra-serotypic antigenic differences in this genotype shift. We characterized the antigenic difference of DENV3 of genotypes II and III in Thailand, utilizing a neutralizing antibody assay with DENV3 vaccine sera and monotypic DENV3 sera. Although there was significant antigenic diversity among the DENV3, it did not clearly associate with the genotype. Our data therefore do not support the role of intra-serotypic antigenic difference in the genotype replacement. Amino acid alignment showed that eight positions are potentially associated with diversity between distinct antigenic subgroups. Most of these amino acids were found in envelope domain II. Some positions (aa81, aa124, and aa172) were located on the surface of virus particles, probably involving the neutralization sensitivity. Notably, the strains of both genotypes II and III showed clear antigenic differences from the vaccine genotype I strain. Whether this differencewill affect vaccine efficacy requires further studies.